Mitochondria are one of the most important components of a cell. Without them, many crucial biochemical processes would not happen. Not only do they host cellular respiration, the process by which food and oxygen is converted into energy, they also send messages to other components within the cell, tailor the cell to perform specific functions, and control both cell growth and cell self-destruction.
Being responsible for so much comes at a cost: biochemical reactions generate free radicals as by-products. While free radicals do have some important benefits when present in the right place and in the right numbers, if their levels are not controlled effectively and overproduction occurs, they can inflict severe damage on the delicate cell components that they encounter.
Naturally, our bodies do try to keep the numbers of free radicals at manageable levels. Much of this task falls to our mitochondria. Because mitochondria are at the core of the energy production process, they are responsible for 90 – 95% of the free radicals in our cells. To keep these free radicals in check, our mitochondria produce a home-grown antioxidant called CoQ10, which they use to line the mitochondrial membrane, giving it a secure, defensive barrier that neutralizes free radicals, helping to protect essential energy production and prevent free radicals from escaping in the main body of the cell, where they can cause damage.
When we are young and healthy, our mitochondria work at maximum efficiency, giving our cells all the energy, they need. We can run and jump, fall and get back up again. We bounce back quickly from injury and illness. As we get older, mitochondria naturally start to decline in function. Indeed, it is thought that mitochondria decline in performance at around 10% per decade, once we hit our thirties. We don’t notice it immediately, but over time, we start to have less energy; we don’t recover as quickly from injury or illness; our organs age; and we start to look and feel older.
What causes mitochondria to slow down? Well, because of the energy production process, they are 10 times more exposed to free radicals than any other part of the cell; and over time, they start to suffer from wear and tear. Damage inflicted on mitochondria may not be enough to kill them but is usually enough to disrupt their normal function. Dysfunctional mitochondria send incorrect messages, decrease energy production and produce more free radicals. In addition, under-performing mitochondria produce less CoQ10, which weakens the mitochondrial wall; this means that less free radicals are neutralized, and the defensive barrier is less secure. Free radicals escape into the cell, where damage starts to accumulate. At this point our cells are in a state of oxidative stress.
Oxidative stress is a big deal. Not only is it thought to be a major cause of the aging process, but it can also cause some serious health issues downstream. In fact, oxidative stress is known to be a precursor to many different health conditions; in the developed world, this includes seven of the top ten most costly to human life.
Reducing the risk of oxidative stress should be high on the list of anyone’s ongoing health priorities.
Minimizing oxidative stress starts with looking after your mitochondria, helping them to keep performing at their best. It should come as no surprise that all the components of a healthy lifestyle – a good diet, regular exercise and adequate sleep – all combine to create an environment in which your mitochondria can thrive.
But it’s important to note, that even if you look after your mitochondria through a healthy lifestyle, they still slow down naturally with age. That is why, along with making healthy choices, taking a supplement that supports mitochondrial performance, is a smart strategy to help you maintain energy levels, protect your cells and support your ongoing well-being and longevity.
MitoQ® is a world-first, mitochondria-targeted CoQ10 antioxidant, which is absorbed through the mitochondrial membrane and directly into the body of the mitochondria, hundreds of times more effectively than regular CoQ10 supplements. The mitochondria use MitoQ® to re-line the mitochondrial membrane, helping to maintain its structural integrity and support the defensive barrier. This means that more free radicals can be neutralized, and their levels can be managed, delivering a double benefit:
Here's how it works: MitoQ® is a shortened form of the antioxidant ubiquinol (CoQ10) with the addition of an ion called Triphenylphosphonium, which gives it a positive charge. These two modifications create a duel effect:
Regular CoQ10 antioxidant supplements are popular and readily available – however, they are largely ineffective. Why? Because they are too big to penetrate the very selective mitochondrial membrane. So, whilst they get into your bloodstream, they are unable to get into the mitochondria itself.
The unique properties of MitoQ® mean that it is absorbed directly into your mitochondria in large concentrations. The inside of the mitochondria and inner membrane is the major site for biochemical reactions, including cellular respiration. This puts MitoQ® exactly where your body needs it the most.
MitoQ® is one of the most-studied mitochondrial-targeted antioxidants. To date, over 50 million US dollars has been spent on independent research and over 300 peer-reviewed articles have been published, testing MitoQ® across a range of health-related applications. Research has shown that after oral administration, MitoQ® rapidly accumulates in mitochondria-rich tissue such as the heart, brain, skeletal muscle, liver and kidney, helping to guard against oxidative stress and maintain healthy function and performance.
Electron shell http://en.wikipedia.org/wiki/Electron_shell
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