750+ independent high-impact, peer-reviewed journals, and 19 clinical trials. Here are some highlights.
HEART
Chronic supplementation with a mitochondrial antioxidant (MitoQ) improves vascular function in healthy older adults
MitoQ decreases free radical production by mitochondria, and significantly supports arterial function in older adults and therefore the health of the arteries. In this clinical trial it was confirmed that: MitoQ greatly improved the ability of arteries to dilate (by 42%). MitoQ significantly supports the health of aorta and factors related to heart lipid metabolism.
Read the summaryEXERCISE/CELL HEALTH
The mitochondria-targeted antioxidant MitoQ, attenuates exercise-induced mitochondrial DNA damage
High-intensity exercise increases our respiration rate and can lead to oxidative stress. The free radicals that are produced during exercise are known to damage our DNA. This study showed that after 3 weeks of chronic supplementation, 20 mg/day of MitoQ was able to protect against exercise-induced DNA damage in young healthy men (20-30 years old). MitoQ significantly reduced both nuclear and mitochondrial DNA damage in the blood and in muscle tissue after intense exercise.
Read the studyEXERCISE
Mitochondria-targeted antioxidant supplementation improves 8km time trial performance in middle-aged trained male cyclist
The study showed that after 4 weeks of MitoQ supplementation, the mean completion time for a time trial was 10.8 seconds faster and an increase of 10 watts of power. MitoQ supplementation may be an effective nutritional strategy to attenuate exercise-induced increases in oxidative damage to lipids and improve cycling performance.
Read the summarySAFETY
The influence of acute high dose MitoQ on urinary kidney injury markers in healthy adults
Results found that acute, high-dose MitoQ supplementation did not result in high concentrations of kidney injury biomarkers compared to placebo samples. Preliminary evidence is that ongoing MitoQ use in the normal range (10mg-20mg) supports kidney health.
Read the summaryCELL HEALTH
MitoQ and CoQ10 supplementation mildly suppresses skeletal muscle mitochondrial hydrogen peroxide levels without impacting mitochondrial function in middle‑aged men
Mitochondria are the main source of oxidative stress in our bodies. Oxidative stress is caused by an imbalance of free radicals and our levels of antioxidants. Over time, oxidative stress can lead to cell damage and have flow-on effects for our health. This study compared the effects of 20 mg/day MitoQ and 200 mg/day CoQ10 on biomarkers of mitochondrial health and oxidative stress in healthy middle-aged men (40-60 years old). After six weeks of supplementation, MitoQ was found to be 24% more effective than CoQ10 at reducing hydrogen peroxide levels in the mitochondria during states of stress. Unlike CoQ10, MitoQ supplementation also increased levels of the important internal antioxidant, catalase, by 36%.
Read the studyEXERCISE
MitoQ supplementation augments acute exercise-induced increases in muscle PGC1α mRNA and improves training-induced increases in peak power independent of mitochondrial content and function in untrained middle-aged men
Regular high-intensity exercise leads to adaptations in our bodies and mitochondria that help improve performance and recovery. This study showed that in untrained middle-aged men, just 10 days of supplementation of 20mg/day MitoQ improved exercise performance in middle-aged men (35-55 years old). MitoQ significantly increased peak power generation during a 20km cycling trial compared to placebo. This result was accompanied by an increase in skeletal muscle PGC1α mRNA expression, a gene activator associated with the regulation of mitochondrial health and function.
Read the studyMore studies
*Intended for a researcher audience, for research purposes only
VASCULAR HEALTH (18)
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Effects of treadmill exercise and MitoQ treatment on vascular function in D-galactose-induced aging rat.. Kim D et al. Korean Journal of Sport Science. 2019, Vol. 30. No.4689-699DOI: 10.24985/kjss.201930.4.689
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MUSCULOSKELETAL HEALTH AND EXERCISE (14)
MitoQ and CoQ10 supplementation mildly suppresses skeletal muscle mitochondrial hydrogen peroxide levels without impacting mitochondrial function in middle-aged men. Pham T et al. European Journal of Applied Physiology. 2020 May 26DOI: 10.1007/s00421-020-04396-4 Source
Targeting reactive oxygen species (ROS) to combat the age-related loss of muscle mass and function. Thoma A et al. Biogeronology. 2020 May 23DOI: 10.1007/s10522-020-09838-x
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MitoQ supplementation improves leg-extension power in healthy late middle-aged and older adults. Bispham NZ et al. The Journal of the Federation of American Societies for Experimental Biology. 2017; 31 (1) (suppl) abs. lb852DOI: 10.1096/fasebj.31.1_supplement.lb852 Source
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Anti-aging potentials of methylene blue for human skin longevity. Xiong Z-M et al. Scientific Reports. 2017 May. 7; 24DOI: 10.1038/s41598-017-02419-3
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Collagen fragmentation promotes oxidative stress and elevates matrix metalloproteinase-1 in fibroblasts in aged human skin. Fisher GJ et al. The American Journal of Pathology. 2009; 174(1): 101–114DOI: 10.2353/ajpath.2009.080599 Source
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