Best CoQ10 supplement for mitochondrial health

Natural production of CoQ10 can decrease with age and lifestyle factors like diet and smoking, and when CoQ10 levels diminish, we tend to see poorly functioning mitochondria and increased free radical damage which is now known to contribute to a whole host of health issues.

There are two forms of CoQ10: ubiquinone and ubiquinol, and the main difference is their oxidation state. 

• Ubiquinone (marketed as CoQ10) is the oxidized form that has been studied most extensively in clinical research. 
• Ubiquinol is the reduced, “active” form of CoQ10 that your body uses directly in energy and antioxidant pathways. The body normally converts ubiquinone to ubiquinol after absorption

Which form of CoQ10 is best?

While CoQ10 supplements have been widely available for many years, research suggests that both CoQ10 (ubiquinone) and ubiquinol face limitations when it comes to supporting mitochondria. Although some benefits have been reported in scientific studies, one key challenge remains: getting enough of the molecule to where it is needed most.

CoQ10 is poorly absorbed by mitochondria

CoQ10 is a large fat-soluble molecule that is absorbed inefficiently and is generally recommended to be taken with dietary fat. Even after absorption, only a small amount is thought to reach the mitochondria due to their highly selective membranes.
This creates a paradox. CoQ10 is required inside mitochondria to support energy production and antioxidant defence, yet conventional CoQ10 supplements are not specifically designed to accumulate there. Ubiquinol, the reduced form of CoQ10, faces similar delivery challenges because it continually cycles between its oxidized and reduced forms as part of normal cellular metabolism.
For those looking to support mitochondrial health specifically, the key question isn't simply which form of CoQ10 to take—it's how effectively that CoQ10 can reach the mitochondria.

Why MitoQ® Mitoquinol may be better than standard CoQ10 supplements

A real breakthrough was discovered in New Zealand by two biochemists in the late 1990s. They realized that because mitochondria have a significant negative charge compared to the rest of the cell, attaching the right positively charged molecule to CoQ10 would achieve targeted delivery to the mitochondria. After years of experimenting with different molecules, they found the optimal method to obtain this mitochondria-targeted molecule, and 'MitoQ^® Mitoquinol' was born.

MitoQ^® Mitoquinol is so effective that the dose can be reduced to ten times less than the regular CoQ10 dose, yet still provide a significantly high amount of mitochondria targeted antioxidants. Additionally, once it neutralizes a free radical, MitoQ® Mitoquinol is recycled back to its active form allowing it to perform this task over and over again.

With 30+ clinical trials and over 1000+ peer reviewed research papers now published, MitoQ^® Mitoquinol has been shown to:

• Reduce reactive oxygen species by up to 48% 
• Support healthy blood flow and flexible arteries 
• Aid in exercise performance and help you achieve faster performance times