Stacking MitoQ Pure and NAD+: The ultimate energy upgrade

Why energy production needs both fuel and function 

MitoQ Pure and NAD+ Dual Action work together to prime your mitochondria, fuel them with NAD+, and protect them from oxidative stress, so your cells (and your body) can perform at their best.  

The MitoQ Pure and NAD+ supplement stack supports energy production, cognitive and cardiovascular health, helping you feel sharper, stronger, and more energized every day. 

To get the most out of your MitoQ Pure and NAD+ stack, take MitoQ Pure first thing in the morning on an empty stomach, and then MitoQ NAD+ Dual Action with breakfast. 

NAD+ as the fuel 

Think of NAD+ (nicotinamide adenine dinucleotide) as the fuel your cells can’t live without. Found in every living cell, NAD+ is essential for turning food into energy in the mitochondria, supports DNA repair, and regulates essential metabolic pathways. 

The challenge is that NAD+ levels naturally decline with age. By the time you reach your mid-40s, you may have lost up to half of your natural supply. At the same time, your cells actually require more NAD+ as you age—meaning your “fuel tank” is running low just when demand is highest. The result? Less energy, reduced focus, and accelerated signs of aging. 

By replenishing NAD+ with clinically studied precursors you give your cells the raw material they need to refill the tank—helping restore energy, clarity, and resilience at the cellular level. 

That’s why NAD+ Dual Action includes two highly bioavailable precursors: 

Together, they fuel your cells with the NAD+ they need to power ATP production and keep you energized. 

Without NAD+, your cells can’t make energy. These precursors help replenish your NAD+ levels, so your body can keep up with the demands of daily life, whether that’s powering through a workout or staying sharp at work. 

MitoQ Pure as the machinery optimizer 

If NAD+ is the fuel, mitochondria are the engines that use it. Even with increased NAD+ levels, energy production depends on how well these tiny powerhouses are functioning. Over time, oxidative stress damages mitochondria, reducing their efficiency in converting NAD+ into ATP, the energy currency of life. 

PQQ and Resveratrol, found in MitoQ NAD+ Dual Action play important roles in mitochondrial health: PQQ stimulates the creation of new mitochondria and enhance their efficiency biogenesis, while resveratrol activates sirtuins—longevity-related proteins that rely on NAD+.  

But more energy production also generates more oxidative stress. Think of oxidative stress as rust accumulating inside the engine. As it builds over time, it accelerates cellular decline.  

This is where MitoQ Pure comes in. Powered by MitoQ® Mitoquinol—the world’s first mitochondria-targeted antioxidant—it works directly inside mitochondria to reduce oxidative stress at its source, supporting their long-term health and function.  

In this way, MitoQ Pure complements NAD+ by ensuring that the extra “fuel” being supplied can be used effectively, supporting more consistent energy production, cellular resilience, and long-term vitality. 

Your mitochondria are your body’s energy engines. Priming them means you’re not just making more NAD+, you’re making sure your cells are ready to use it efficiently, so you feel the benefits in energy, focus, and long-term vitality. 

The science behind the stack 

Reduced oxidative stress 

One of the biggest barriers to healthy energy production and properly utilizing NAD+ is  oxidative stress, an imbalance between free radicals (reactive oxygen species, or ROS) and your body’s natural defences.  

The solution lies in antioxidants, which neutralize free radicals before they cause harm. But most antioxidants can’t reach the mitochondria—the tiny energy factories inside your cells where the majority of free radicals are produced. That’s where MitoQ Pure is different. 

MitoQ Pure is powered by MitoQ® Mitoquinol, a molecule is uniquely designed to penetrate the mitochondrial membrane and work at the very site where oxidative stress begins. By acting at the source, it helps reduce oxidative damage and protect energy production at the cellular level. 

In clinical studies, MitoQ® Mitoquinol has been shown to: 

Alongside MitoQ, Resveratrol and PQQ further support the body’s defences by activating internal antioxidant pathways such as NRF-2, which upregulates your own natural protective systems. Together, this stack helps strengthen the foundations of long-term cellular health. 

Improved mitochondrial biogenesis 

One way to improve NAD utilization is to make more mitochondria (also known as mitochondrial biogenesis). More mitochondria mean more capacity to produce energy.  

More mitochondria = better energy, faster recovery, and stronger performance. 

What to expect from the combination 

Boosted focus  

When it comes to mental clarity, mitochondria play as critical a role in the brain. MitoQ Pure helps by reducing oxidative stress—a key contributor to energy crashes and brain fog.  

NAD+ is equally important for focus. By activating sirtuins, it supports DNA repair and cellular maintenance in high-demand tissues like the brain. This helps neurons remain resilient under stress. 

On top of that, PQQ—a core ingredient in MitoQ® NAD+ Dual Action—has been studied for its ability to improve cognitive function. In clinical research, PQQ has been shown to support:  

Physical energy & performance 

Whether you’re training intensely or staying active as you age, your mitochondria are doing the heavy lifting behind the scenes. Supporting them with the right ingredients—Mitoquinol (MitoQ Pure) alongside NAD+ and PQQ from MitoQ NAD+ Dual Action—creates the foundation for strength and performance.  

As a mitochondria-targeted antioxidant, Mitoquinol reduces oxidative stress directly at the source, helping protect mitochondrial DNA and maintain efficiency during exertion. It’s been shown to improve oxygen uptake and VO₂peak, supporting better performance and helping sustain mobility with age. 

Meanwhile, PQQ contributes to improved muscle function by stimulating mitochondrial biogenesis. In human studies, it has been linked to gains in grip strength and increased muscle power.  

Enhanced recovery and resilience 

Energy and performance are only part of the story—true vitality also depends on how quickly and effectively the body can recover. The MitoQ Pure and NAD+ stack due to the inclusion of PQQ helps your body bounce back faster and stay protected: 

Whether you're training hard or aging gracefully, this MitoQ Pure+ NAD+ stack helps your cells bounce back faster. 

How to use the stack effectively 

Timing, dosage & synergy 

Consistency is key, these cellular benefits build over time 

Who can benefit most 

Key takeaways

The combination of NAD+ Dual action and MitoQ Pure helps to prime, fuel, and protect the mitochondria, while making the most of energy production. Together, they support energy, focus, recovery, and resilience 

Backed by clinical researched ingredients, the MitoQ Pure and NAD+ supplement stack is a science-driven solution for cellular health and longevity.