Target and rejuvenate cells
Here’s what you might expect taking MitoQ® Mitoquinol, according to the science.
Like fast results? It only takes one hour after taking one of our MitoQ® Mitoquinol supplements to begin rejuvenating your mitochondria.
From there, you can expect to unlock evidence-based benefits from your cells to whole body systems: supporting vitality, cellular longevity, and whole-body health.
MitoQ® Mitoquinol is a powerful targeted antioxidant designed to tackle free radicals at the source – your mitochondria. Knowing what that means for your body might not be so intuitive, so we have summarized what a MitoQ® Mitoquinol journey might look like from your first dose onward.
Hour 1 - MitoQ® Mitoquinol enters your cells.
After being swallowed, MitoQ® Mitoquinol is quickly absorbed by the body. It takes around thirty minutes for MitoQ® Mitoquinol to be absorbed from the gut into the bloodstream(1). Once in the bloodstream, MitoQ® Mitoquinol is rapidly transported to different organ tissues where it can get to work. Because of its unique structure, MitoQ® Mitoquinol can pass through all biological membranes, including the tightly controlled blood brain barrier.
MitoQ® Mitoquinol is mainly used in tissues that have high energy demands and therefore a high number of mitochondria, and can be taken up into the cells of organs like the heart and liver within one hour.
Hour 2 – MitoQ® Mitoquinol targets your mitochondria.
Once inside your cells, MitoQ® Mitoquinol is quickly drawn into the mitochondria within around 20-40 minutes(1,2). As it enters these organelles, MitoQ® Mitoquinol sticks to the inner mitochondrial wall(2), where it is perfectly positioned to remove the excess free radicals that are made during energy production, and protect the membrane from damage.
Day 1 – Controlling free radicals
Once inside the mitochondria, MitoQ® Mitoquinol gets to work neutralizing free radicals and protecting against oxidative stress. In a study on human fat cells, MitoQ® Mitoquinol has been shown to decrease free radicals in as little as 24 hours(3). Once MitoQ Mitoquinol neutralizes a free radical, it is re-activated again by the mitochondria itself, meaning that one molecule of MitoQ® Mitoquinol can be used repeatedly; think of it like a renewable antioxidant(4).
The First Week – MitoQ® Mitoquinol protects cells against oxidative stress.
After controlling free radical build up for seven days we start to see reductions in oxidative stress and the beginnings of cellular rejuvenation. In a study of human skin cells, one week of MitoQ® Mitoquinol intervention helped to mitigate the effects of mild oxidative stress, preventing the shortening of telomeres (the protective caps on DNA) and increasing healthy cell lifespan(5).
Day 10 – MitoQ® Mitoquinol enhances the effects of exercise.
Now we can see how controlling free radicals starts to benefit our body. After continual supplementation for over a week, MitoQ® Mitoquinol starts to have synergistic effects with exercise by enhancing the effects of high-intensity training. Exercise, especially high-intensity exercise, requires a lot of energy. This can put our mitochondria into sixth gear as they pump out ATP and drive up the amounts of free radicals being produced.
In only 10 days, MitoQ® Mitoquinol starts to improve our muscle’s responses to exercise. In a human clinical trial, 20 mg MitoQ® Mitoquinol a day helped untrained men improve their muscle’s peak power output by 67% (measured as peak power (W) at VO2max)(6).
It wasn’t only peak power that improved, researchers also identified a number of performance-related biomarkers that were enhanced by MitoQ® Mitoquinol. One of them is the growth factor, VEGF. VEGF promotes the formation of new blood vessels which increases the amount of oxygen and nutrients that can be delivered to muscles, making them more efficient. MitoQ® Mitoquinol also doubled the expression of PGC1-α, which is known to regulate our metabolism, muscle efficiency, and mitochondrial biogenesis
Week 3 – MitoQ® Mitoquinol protects against DNA damage.
Intense workouts can really push ourselves to the edge – both mentally and physically. They’re a bit of a double-edged sword. On one hand, you’re challenging yourself on the journey to better health and fitness, but on the other – if you’re untrained (or just not used to the intensity) your body isn’t really adapted to these kinds of workouts. This can put a strain on your cells as your mitochondria work overtime to provide you with ATP. This ‘overtraining’ can cause damage to DNA if free radicals build up in the cell.
In one study in healthy males, 3 weeks of continual MitoQ® Mitoquinol supplementation was shown to reduce both nuclear and mitochondrial DNA damage: supporting DNA integrity after exercise(7). This makes MitoQ® Mitoquinol a powerful aid to help mitigate the negative effects of intense exercise, especially in untrained, or recreationally active people.
Week 4 – MitoQ® Mitoquinol improves exercise performance
Now we are at the one-month mark! This is where the body starts to get into its new flow, and MitoQ® Mitoquinol’s exercise benefits are not only felt by beginners but also trained athletes. In a study on cyclists, taking 20 mg/day of MitoQ® Mitoquinol improved their performance and increased their muscle power output by 4.4%. While it might sound like a small number, that’s huge in the world of competitive cycling, and meant those that took MitoQ® Mitoquinol shaved an average of 10.8 seconds off their finishing time!(8) That’s not all, MitoQ® Mitoquinol also reduced their levels of oxidative stress during the time trial by up to 18.3%, meaning that not only did the athletes perform better, but they did so with less cell stress!
MitoQ® Mitoquinol isn't just a strong antioxidant on its own; it also helps boost the body's natural antioxidant defenses, making it particularly effective at combating oxidative stress. One study found that after just four weeks of MitoQ® Mitoquinol supplementation, cyclists saw an increase in their levels of glutathione peroxidase (GPx). GPx is the key antioxidant enzyme in the mitochondria, responsible for breaking down harmful peroxides. By enhancing the cell's overall antioxidant capacity, MitoQ® Mitoquinol was able to reduce excess reactive oxygen species by up to 48%.(9)
Week 6 – Advanced support for cardiovascular health and aging.
Here’s where things start to get really exciting, and we start to notice MitoQ® Mitoquinol effects in areas outside of fitness. By the six-week mark, we see the impressive benefits of MitoQ® Mitoquinol for heart health. Our cardiovascular system is particularly sensitive to oxidative stress, which is why it’s important to monitor our heart health as we age, and our antioxidant reserves can’t quite keep up with the amount of free radicals we produce.
One of the areas impacted is the endothelial lining of our blood vessels. This delicate tissue helps to control the narrowing and widening of blood vessels essentially controlling blood flow. As we age, these tissues can start to stiffen and become less responsive. While aging is just a fact of life, we can support our heart health by reducing oxidative stress. This is where MitoQ® Mitoquinol shines.
In a study published by the American Heart Association, just six weeks of 20mg/day MitoQ® Mitoquinol has been shown to mitigate vascular aging by reducing oxidized LDL- by 13% and improving vasodilation by up to 42%!(10) Not only that, but MitoQ® Mitoquinol also helped to reduce age-related aortic stiffness, a common aging biomarker that is difficult to reverse.
It is a common concern that as we age, we will become frail and increasingly dependent on others to help us carry out simple tasks. One way to keep healthy and maintain independence as we age is to prioritize strength and mobility. A key indicator of mobility is leg extension power, directly related to quadricep strength. In a study focused on late to middle-aged healthy adults, six weeks of 20 mg/day MitoQ Mitoquinol helped to increase leg extension power by 11% compared to placebo(11).
Month 3 – Continual cell support.
Now MitoQ® Mitoquinol has been working diligently within your cells to keep free radicals at bay for over three months. Our cells have limited life spans, and in this time, all of your skin cells, intestinal lining, taste buds, red blood cells, and others have been turned over into new cells that are reaping the rewards of less cell stress.
These cell cycles are a reason why it’s important to stay consistent with your supplements with MitoQ® Mitoquinol. Free radicals aren’t just a one and done deal; they are produced continually throughout your life and cell stress can become imbalanced when we are stressed too. By maintaining consistent levels of MitoQ® Mitoquinol, you are supporting your cells against stress long term.
MitoQ pure customers share their reviews.
ROBERT S.
“I was skeptical at first... but sure enough... within 90 days I started feeling good; better in myself. First supplement that I’ve taken that I can honestly say I feel the benefit from.”
NEVILLE T.
“I have taken MitoQ for 2 months. I do believe I got an improvement in strength and resilience after 4 to 6 weeks. I feel it has held steady since then. At 72 years old a small improvement is great.”
ANNA A.
"I wasn't expecting to notice the change so instantly, but I cannot believe the difference in my energy from day one! Highly recommend."
References
Full list of references.
1. Zhang, J. et al. MitoQ ameliorates testis injury from oxidative attack by repairing mitochondria and promoting the Keap1-Nrf2 pathway. Toxicology and Applied Pharmacology 370, 78–92 (2019).
2. Kelso, G. F. et al. Selective targeting of a redox-active ubiquinone to mitochondria within cells: antioxidant and antiapoptotic properties. J Biol Chem 276, 4588–4596 (2001).
3. Hirzel, E. et al. Differential modulation of ROS signals and other mitochondrial parameters by the antioxidants MitoQ, resveratrol and curcumin in human adipocytes. Journal of Receptors and Signal Transduction 33, 304–312 (2013).
4. James, A. M., Cochemé, H. M., Smith, R. A. J. & Murphy, M. P. Interactions of Mitochondria-targeted and Untargeted Ubiquinones with the Mitochondrial Respiratory Chain and Reactive Oxygen Species: IMPLICATIONS FOR THE USE OF EXOGENOUS UBIQUINONES AS THERAPIES AND EXPERIMENTAL TOOLS *♦. Journal of Biological Chemistry 280, 21295–21312 (2005).
5. Saretzki, G., Murphy, M. P. & Von Zglinicki, T. MitoQ counteracts telomere shortening and elongates lifespan of fibroblasts under mild oxidative stress. Aging Cell 2, 141–143 (2003).
6. Broome, S. C. et al. MitoQ supplementation augments acute exercise-induced increases in muscle PGC1α mRNA and improves training-induced increases in peak power independent of mitochondrial content and function in untrained middle-aged men. Redox Biology 53, 102341 (2022).
7. Williamson, J., Hughes, C. M., Cobley, J. N. & Davison, G. W. The mitochondria-targeted antioxidant MitoQ, attenuates exercise-induced mitochondrial DNA damage. Redox Biology 36, 101673 (2020).
8. Broome, S. C., Braakhuis, A. J., Mitchell, C. J. & Merry, T. L. Mitochondria-targeted antioxidant supplementation improves 8 km time trial performance in middle-aged trained male cyclists. Journal of the International Society of Sports Nutrition 18, 58 (2021).
9. Aminizadeh, S. et al. MitoQ Supplementation During Vigorous Training Improves Reactive Oxygen Species, Glutathione Peroxidase, and miRNAs Regulating Vascular Inflammation in Cyclists. Braz. arch. biol. technol. 66, e23220914 (2023).
10. Rossman, M. J. et al. Chronic Supplementation With a Mitochondrial Antioxidant (MitoQ) Improves Vascular Function in Healthy Older Adults. Hypertension 71, 1056–1063 (2018).
11. Bispham, N. Z. et al. MitoQ Supplementation Improves Leg-Extension Power in Healthy Late Middle-Aged and Older Adults. The FASEB Journal 31, lb852–lb852 (2017).
