Founded in science, studied around the world, clinically tested.

HIF-1α promotes cellular growth in lymphatic endothelial cells exposed to chronically elevated pulmonary lymph flow. Boehme JT et al. Scientific Reports. 2016DOI: 10.1038/s41598-020-80882-1 Source

Mitoquinone (MitoQ) Inhibits Platelet Activation Steps by Reducing ROS Levels. Méndez D et al. International Journal of Molecular Sciences. 2021DOI: 10.3390/ijms21176192 Source

Effect of treadmill exercise and MitoQ treatment on vascular function in D-galactose-induced senescent mice. Kim DW. 2020DOI: 10.24985/kjss.2019.30.4.689 Source

Mitoquinone attenuates vascular calcification by suppressing oxidative stress and reducing apoptosis of vascular smooth muscle cells via the Keap1/Nrf2 pathway. Cui, L et al. Free Radical Biology and Medicine. 2020DOI: 10.1016/j.freeradbiomed.2020.09.028 Source

Doxorubicin-Induced Oxidative Stress and Endothelial Dysfunction in Conduit Arteries Is Prevented by Mitochondrial-Specific Antioxidant Treatment. Clayton ZS et al. JACC. CardioOncology. 2021DOI: 10.1016/j.jaccao.2020.06.010 Source

Mitochondrial reactive oxygen species scavenging attenuates thrombus formation in a murine model of sickle cell disease. Annarapu GK et al. Journal of thrombosis and haemostasis: JTH. 2022DOI: 10.1111/jth.15298 Source

Reactive Oxygen Species are Essential for Placental Angiogenesis During Early Gestation. Yang Y et al. Oxidative medicine and cellular longevity. 2014DOI: 10.1155/2022/4290922 Source

Mitoquinone ameliorates cigarette smoke-induced airway inflammation and mucus hypersecretion in mice. Yang D et al. International Immunopharmacology. 2021DOI: 10.1016/j.intimp.2020.107149 Source

Autophagy-mitophagy induction attenuates cardiovascular inflammation in a murine model of Kawasaki disease vasculitis. Marek-Iannucci S et al. JCI Insight. 2021DOI: 10.1172/jci.insight.151981 Source

MicroRNA-210-mediated mtROS confer hypoxia-induced suppression of STOCs in ovine uterine arteries. Hu XQ et al. British Journal of Pharmacology. 2022DOI: 10.1111/bph.15914 Source

Mitochondrial-targeted antioxidant supplementation for improving age-related vascular dysfunction in humans: A study protocol. Murray K.O. et al. Frontiers in Physiology. 2022DOI: 10.3389/fphys.2022.980783 Source

Acute mitochondrial antioxidant intake improves endothelial function, antioxidant enzyme activity, and exercise tolerance in patients with peripheral artery disease. Park SY et al. American Journal of Physiology. Heart and Circulatory Physiology. 2020DOI: 10.1152/ajpheart.00235.2020 Source

Effect of Combined Endurance Training and MitoQ on Cardiac Function and Serum Level of Antioxidants, NO, miR-126, and miR-27a in Hypertensive Individuals. Masoumi-Ardakani et al. BioMed Research International. 2022DOI: 10.1155/2022/8720661 Source

Vasodilatory and vascular mitochondrial respiratory function with advancing age: Evidence of a free radically-mediated link in the human vasculature. Park SH et al. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 2020DOI: 10.1152/ajpregu.00268.2019 Source

Chronic supplementation with a mitochondrial antioxidant (MitoQ) improves vascular function in healthy older adults. Rossman MJ et al. Hypertension (Dallas, Tex.: 1979). 2018DOI: 10.1161/HYPERTENSIONAHA.117.10787 Source

Reactive oxygen species induced Ca2+ influx via TRPV4 and microvascular endothelial dysfunction in the SU5416/hypoxia model of pulmonary arterial hypertension. Suresh K et al. American Journal of Physiology-Lung Cellular and Molecular Physiology. 2020DOI: 10.1152/ajplung.00430.2017 Source

Age-related endothelial dysfunction in human skeletal muscle feed arteries: the role of free radicals derived from mitochondria in the vasculature. Park S Y et al. Acta Physiologica (Oxford, England). 2018DOI: 10.1111/apha.12893 Source

Mitochondria-targeted antioxidant therapy with MitoQ ameliorates aortic stiffening in old mice. Gioscia-Ryan RA et al. Journal of Applied Physiology (Bethesda, Md.: 1985). 2018DOI: 10.1152/japplphysiol.00670.2017 Source

Voluntary aerobic exercise increases arterial resilience and mitochondrial health with aging in mice. Gioscia-Ryan RA et al. Aging (Albany NY). 2019DOI: 10.18632/aging.101099 Source

Mitochondria-targeted antioxidant MitoQ intercepts superoxide radical formation under acute hypoxia: Evaluation of the oxidative stress in murine pulmonary arterial smooth muscle cells by electron paramagnetic resonance spectroscopy. Scheibe S et al. Free Radical Biology and Medicine. 2018DOI: 10.1016/j.freeradbiomed.2016.04.106 Source

Transgenic overexpression of uncoupling protein 2 attenuates salt-induced vascular dysfunction by inhibition of oxidative stress. Ma S et al. American Journal of Hypertension. 2016DOI: 10.1093/ajh/hpt225 Source

Redox signaling via oxidative inactivation of PTEN modulates pressure-dependent myogenic tone in rat middle cerebral arteries. Gebremedhin D et al. PLoS One. 2012DOI: 10.1371/journal.pone.0068498 Source

Mitochondrial reactive oxygen species enhance AMP-activated protein kinase activation in the endothelium of patients with coronary artery disease and diabetes. Mackenzie RM et al. Clinical Science. 2014DOI: 10.1042/CS20120239 Source

Evidence for a relationship between mitochondrial Complex I activity and mitochondrial aldehyde dehydrogenase during nitroglycerin tolerance: Effects of mitochondrial antioxidants. Garcia-Bou R et al. Biochim Biophys Acta (BBA)-Bioenergetics. 2013DOI: 10.1016/j.bbabio.2012.02.013 Source

Complex I dysfunction and tolerance to nitroglycerin: an approach based on mitochondrial-targeted antioxidants. Esplugues JV et al. Circulation Resarch. 2012DOI: 10.1161/01.RES.0000250430.62775.99 Source

Prohibitin-1 Is a Dynamically Regulated Blood Protein With Cardioprotective Effects in Sepsis. Mattox TA et al. Journal of the American Heart Association. 2021DOI: 10.1161/JAHA.120.019877 Source

Ceramide modulates electrophysiological characteristics and oxidative stress of pulmonary vein cardiomyocytes. Huang SY et al. European Journal of Clinical Investigation. 2022DOI: 10.1111/eci.13690 Source

[Inhibition of mitochondrial reactive oxygen species reduces high glucose-induced pyroptosis and ferroptosis in H9C2 cardiac myocytes]. Wang J et al. Nan Fang Yi Ke Da Xue Xue Bao = Journal of Southern Medical University. 2021DOI: 10.12122/j.issn.1673-4254.2021.07.03 Source

mTOR contributes to endothelium-dependent vasorelaxation by promoting eNOS expression and preventing eNOS uncoupling. Wang Y et al. Communications Biology. 2022DOI: 10.1038/s42003-022-03653-w Source

Endurance training and MitoQ supplementation increases PERM1 and SMYD1 gene expression and improves hemodynamic parameters in cardiac muscle of male Wistar rats. Mahboube ST et al. 2022DOI: 10.21203/rs.3.rs-1803848/v1 Source

Mitochondrial targeted antioxidants, mitoquinone and SKQ1, not vitamin C, mitigate doxorubicin-induced damage in H9c2 myoblast: pretreatment vs. co-treatment. Sacks B et al. BMC Pharmacology and Toxicology. 2021DOI: 10.1186/s40360-021-00518-6 Source

MicroRNA-210 Controls Mitochondrial Metabolism and Protects Heart Function in Myocardial Infarction. Song R et al. Circulation. 2022DOI: 10.1161/CIRCULATIONAHA.121.056929 Source

Mitochondrial Oxidative Stress Induces Cardiac Fibrosis in Obese Rats through Modulation of Transthyretin. Martínez-Martínez E et al. International Journal of Molecular Sciences. 2022DOI: 10.3390/ijms23158080 Source

The Crosstalk between Cardiac Lipotoxicity and Mitochondrial Oxidative Stress in the Cardiac Alterations in Diet-Induced Obesity in Rats - PubMed. Jiménez-González S et al. 2020DOI: 10.3390/cells9020451. Source

The Interplay of Mitochondrial Oxidative Stress and Endoplasmic Reticulum Stress in Cardiovascular Fibrosis in Obese Rats. Souza-Neto FV et al. Antioxidants (Basel, Switzerland). 2021DOI: 10.3390/antiox10081274 Source

Mitochondrial Oxidative Stress Promotes Cardiac Remodeling in Myocardial Infarction through the Activation of Endoplasmic Reticulum Stress. Souza-Neto FV et al. Antioxidants (Basel, Switzerland). 2022DOI: 10.3390/antiox11071232 Source

Effect of mitochondrial-targeted antioxidants on glycaemic control, cardiovascular health, and oxidative stress in humans: A systematic review and meta-analysis of randomized controlled trials. Mason SA et al. Diabetes, Obesity & Metabolism. 2022DOI: 10.1111/dom.14669 Source

Endurance training and MitoQ supplementation improve spatial memory, VEGF expression, and neurogenic factors in hippocampal tissue of rats. Zadeh HJ et al. Journal of Clinical and Translational Research. 2023DOI: 10.18053/jctres.09.202301.001 Source

Chronic mitochondria antioxidant treatment in older adults alters the circulating milieu to improve endothelial cell function and mitochondrial oxidative stress. Murray KO et al. American Journal of Physiology-Heart and Circulatory Physiology. 2023DOI: 10.1152/ajpheart.00270.2023 Source

Cyclovirobuxine D protects against diabetic cardiomyopathy by activating Nrf2-mediated antioxidant responses. Jiang Z et al. Scientific Reports. 2020DOI: 10.1038/s41598-020-63498-3 Source

Regulation of mitochondrial fragmentation in microvascular endothelial cells isolated from the SU5416/hypoxia model of pulmonary arterial hypertension. Suresh K et al. American Journal of Physiology-Lung Cellular and Molecular Physiology. 2019DOI: 10.1152/ajplung.00396.2018 Source

Mitoquinone ameliorates pressure overload-induced cardiac fibrosis and left ventricular dysfunction in mice. Goh KY et al. Redox Biology. 2019DOI: 10.1016/j.redox.2019.101100 Source

G protein-coupled estrogen receptor (GPER) deficiency induces cardiac remodeling through oxidative stress. Wang H et al. Translational Research. 2018DOI: 10.1016/j.trsl.2018.04.005 Source

Ice-free cryopreservation of heart valve tissue: The effect of adding MitoQ to a VS83 formulation and its influence on mitochondrial dynamics. Sui Y et al. Cryobiology. 2018DOI: 10.1016/j.cryobiol.2018.01.008 Source

P 165 - The role of mitochondrial reactive oxygen species in the response of the pulmonary vasculature to hypoxia and right heart remodeling. Scheibe S et al. Free Radical Biology and Medicine. 2017DOI: 10.1016/j.freeradbiomed.2017.04.250 Source

Differences in the profile of protection afforded by TRO40303 and mild hypothermia in models of cardiac ischemia/reperfusion injury. Hannson MJ et al. European Journal of Pharmacology. 2015DOI: 10.1016/j.ejphar.2015.04.009 Source

Cardiomyocyte mitochondrial oxidative stress and cytoskeletal breakdown in the heart with a primary volume overload. Yancey DM et al. American Journal of Physiology-Heart and Circulatory Physiology. 2015DOI: 10.1152/ajpheart.00638.2014 Source

Mitochondria transmit apoptosis signalling in cardiomyocyte-like cells and isolated hearts exposed to experimental ischemia-reperfusion injury. Neuzil J et al. Redox Report: Communications in Free Radical Research. 2007DOI: 10.1179/135100007X200227 Source

Slow calcium waves and redox changes precede mitochondrial permeability transition pore opening in the intact heart during hypoxia and reoxygenation. Davidson SM et al. Cardiovascular Research. 2012DOI: 10.1093/cvr/cvr349 Source

Resolution of Mitochondrial Oxidative Stress Rescues Coronary Collateral Growth in Zucker Obese Fatty Rats. Fen Pung Y et al. Arteriosclerosis, Thrombosis and Vascular Biology. 2012DOI: 10.1161/ATVBAHA.111.241802 Source

Novel insights into interactions between mitochondria and xanthine oxidase in acute cardiac volume overload. Gladden JD et al. Free Radical Biology and Medicine. 2011DOI: 10.1016/j.freeradbiomed.2011.08.022 Source

Targeting an antioxidant to mitochondria decreases cardiac ischemia-reperfusion injury. Adlam VJ et al. FASEB journal: official publication of the Federation of American Societies for Experimental Biology. 2005DOI: 10.1096/fj.05-3718com Source

Generation of mitochondrial reactive oxygen species is controlled by ATPase inhibitory factor 1 and regulates cognition. Esparza-Moltó PB et al. PLoS biology. 2021DOI: 10.1371/journal.pbio.3001252 Source

Preeclamptic placentae release factors that damage neurons: implications for foetal programming of disease. Scott H et al. Neuronal Signaling. 2018DOI: 10.1042/NS20180139 Source

The Role of Pink1-Mediated Mitochondrial Pathway in Propofol-Induced Developmental Neurotoxicity. Liang C et al. Neurochemical Research. 2021DOI: 10.1007/s11064-021-03359-1 Source

Accelerated aging of the brain transcriptome by the common chemotherapeutic doxorubicin. Cavalier AN et al. Experimental Gerontology. 2021DOI: 10.1016/j.exger.2021.111451 Source

Mitochondrial Reactive Oxygen Species Mediate Activation of TRPV1 and Calcium Entry Following Peripheral Sensory Axotomy - PubMed. Kievit B. 2022DOI: 10.3389/fnmol.2022.852181 Source

Recent Advances in Molecular Pathways and Therapeutic Implications Targeting Mitochondrial Dysfunction for Alzheimer's Disease. Dhapola R et al. Molecular Neurobiology. 2022DOI: 10.1007/s12035-021-02612-6 Source

Mitigation of CNS oxygen toxicity seizures: evaluating the neuroprotective effects of L-NAME versus Mitoquinone during exposure to 5 ATA O2 in freely behaving Sprague-Dawley rats. Hinojo CM et al. The FASEB Journal. 2022DOI: 10.1096/fasebj.2022.36.S1.R4180 Source

Inhibiting amyloid beta (1-42) peptide-induced mitochondrial dysfunction prevents the degradation of synaptic proteins in the entorhinal cortex. Olajide OJ et al. Frontiers in Aging Neuroscience. 2022DOI: 10.3389/fnagi.2022.960314 Source

Long-term mitochondrial stress induces early steps of Tau aggregation by increasing reactive oxygen species levels and affecting cellular proteostasis. Samluk L et al. Molecular Biology of the Cell. 2022DOI: 10.1091/mbc.E21-11-0553 Source

Perturbed actin cap as a new personalized biomarker in primary fibroblasts of Huntington's disease patients. Gharaba S et al. Frontiers in Cell and Developmental Biology. 2023DOI: 10.3389/fcell.2023.1013721 Source

Apolipoprotein E Polymorphism Impacts White Matter Injury Through Microglial Phagocytosis After Experimental Subarachnoid Hemorrhage. Li C et al. Neuroscience. 2023DOI: 10.1016/j.neuroscience.2023.05.020 Source

Quinones as Neuroprotective Agents. Cores Á et al. Antioxidants. 2023DOI: 10.3390/antiox12071464 Source

A mitochondrial-targeted antioxidant (MitoQ) improves motor coordination and reduces Purkinje cell death in a mouse model of ARSACS. Márquez BT et al. Neurobiology of Disease. 2023DOI: 10.1016/j.nbd.2023.106157 Source

CREB Protects against Temporal Lobe Epilepsy Associated with Cognitive Impairment by Controlling Oxidative Neuronal Damage. Xing et al. Neurodegenerative Diseases. 2020DOI: 10.1159/000507023 Source

Neuroprotective Benefits of Exercise and MitoQ on Memory Function, Mitochondrial Dynamics, Oxidative Stress, and Neuroinflammation in D-Galactose-Induced Aging Rats. Jeong et al. Brain Sciences. 2021DOI: 10.3390/brainsci11020164 Source

Mitochondria: Novel Mechanisms and Therapeutic Targets for Secondary Brain Injury After Intracerebral Hemorrhage. Chen et al. Frontiers in Aging Neuroscience. 2021DOI: 10.3389/fnagi.2020.615451 Source

Treating Neurodegenerative Disease with Antioxidants: Efficacy of the Bioactive Phenol Resveratrol and Mitochondrial-Targeted MitoQ and SkQ. Shinn et al. Antioxidants. 2021DOI: 10.3390/antiox10040573 Source

Effective therapeutic strategies in a preclinical mouse model of Charcot–Marie–Tooth disease. Nuevo-Tapioles et al. Human Molecular Genetics. 2021DOI: 10.1093/hmg/ddab207 Source

Mitochondrial, exosomal miR137-COX6A2 and gamma synchrony as biomarkers of parvalbumin interneurons, psychopathology, and neurocognition in schizophrenia. Khadimallah et al. Molecular Psychiatry. 2022DOI: 10.1038/s41380-021-01313-9 Source

Mitoquinone supplementation alleviates oxidative stress and pathologic outcomes following repetitive mild TBI at a chronic time point. Tabet et al. Experimental Neurology. 2022DOI: 10.1016/j.expneurol.2022.113987 Source

The peroxisomal fatty acid transporter ABCD1/PMP-4 is required in the C. elegans hypodermis for axonal maintenance: A worm model for adrenoleukodystrophy. Coppa A et al. Free Radical Biology and Medicine. 2020DOI: 10.1016/j.freeradbiomed.2020.01.177 Source

Mitoquinone alleviates vincristine-induced neuropathic pain through inhibiting oxidative stress and apoptosis via the improvement of mitochondrial dysfunction. Chen X et al. Biomedicine & Pharmacotherapy. 2020DOI: 10.1016/j.biopha.2020.110003 Source

Involvement of oxidative stress and mitochondrial mechanisms in air pollution-related neurobiological impairments. Salvi A et al. Neurobiology of Stress. 2020DOI: 10.1016/j.ynstr.2019.100205 Source

Role of the mitochondrial calcium uniporter in Mg2+-free-induced epileptic hippocampal neuronal apoptosis. Li Y et al. International Journal od Neuroscience. 2020DOI: 10.1080/00207454.2020.1715978 Source

Neuroprotective effects of mitoquinone and oleandrin on Parkinson’s disease model in zebrafish. Ünal I et al. International Journal of Neuroscience. 2020DOI: 10.1080/00207454.2019.1698567 Source

The interplay between redox signalling and proteostasis in neurodegeneration: In vivo effects of a mitochondria-targeted antioxidant in Huntington's disease mice. Pinho BR et al. Free Radical Biology and Medicine. 2020DOI: 10.1016/j.freeradbiomed.2019.11.021 Source

Mitophagy reduces oxidative stress via Keap1/Nrf2/PHB2 pathway after SAH in rats. Zhang T et al. Stroke. 2019DOI: 10.1161/STROKEAHA.118.021590 Source

Mitoquinone attenuates blood-brain barrier disruption through Nrf2/PHB2/OPA1 pathway after subarachnoid hemorrhage in rats. Zhang et al. Experimental Neurology. 2019DOI: 10.1016/j.expneurol.2019.02.009 Source

Therapeutic potential of the mitochondria-targeted antioxidant MitoQ in mitochondrial-ROS induced sensorineural hearing loss caused by Idh2 deficiency. Kim YR et al. Redox Biology. 2019DOI: 10.1016/j.redox.2018.11.013 Source

Effects of NADPH Oxidase Inhibitors and Mitochondria-Targeted Antioxidants on Amyloid β1-42-Induced Neuronal Deaths in Mouse Mixed Cortical Cultures. Hwang S et al. Chonnam Medical Journal. 2018DOI: 10.4068/cmj.2018.54.3.159 Source

Mitochondrial-targeted antioxidant MitoQ provides neuroprotection and reduces neuronal apoptosis in experimental traumatic brain injury possibly via the Nrf2-ARE pathway. Zhou J et al. American Journal of Translational Research. 2018;10(6):1887-1899. eCollection 2018Source

Neuronal Dysfunction Associated with Cholesterol Deregulation. Marcuzzi A et al. International Journal of Molecular Sciences. 2018DOI: 10.3390/ijms19051523 Source

Mitigating peroxynitrite mediated mitochondrial dysfunction in aged rat brain by mitochondria-targeted antioxidant MitoQ. Maiti AK et al. Biogerontology. 2018DOI: 10.1007/s10522-018-9756-6 Source

Mitochondrial rescue prevents glutathione peroxidase-dependent ferroptosis. Jelinek A et al. Free Radical Biology and Medicine. 2018DOI: 10.1016/j.freeradbiomed.2018.01.019 Source

Selective Mitochondrial Targeting Exerts Anxiolytic Effects In Vivo. Nussbaumer M et al. Neuropsychopharmacology. 2016DOI: 10.1038/npp.2015.341 Source

Mitochondrial redox and pH signaling occurs in axonal and synaptic organelle clusters. Breckwoldt MO et al. Scientific Reports. 2016DOI: 10.1038/srep23251 Source

Mitochondria-derived reactive oxygen species mediate caspase-dependent and -independent neuronal deaths. Manus MJ et al. Mol Cell Neurosci. 2014DOI: 10.1016/j.mcn.2014.09.002 Source

The LRRK2 inhibitor GSK2578215A induces protective autophagy in SH-SY5Y cells: involvement of Drp-1-mediated mitochondrial fission and mitochondrial-derived ROS signaling. Saez-Atienzar S et al. Cell Death & Disease. 2014DOI: 10.1038/cddis.2014.320 Source

Neurological deficits caused by tissue hypoxia in neuroinflammatory disease. Davies Al et al. Annals of Neurology. 2013DOI: 10.1002/ana.24006 Source

Glucagon-Like Peptide-1 Cleavage Product GLP-1(9-36) Amide Rescues Synaptic Plasticity and Memory Deficits in Alzheimer's Disease Model Mice. Ma T et al. The Journal of Neuroscience. 2012DOI: 10.1523/JNEUROSCI.2107-12.2012 Source

Amyloid β-Induced Impairments in Hippocampal Synaptic Plasticity Are Rescued by Decreasing Mitochondrial Superoxide. Ma T et al. The Journal of Neuroscience. 2011DOI: 10.1523/JNEUROSCI.6566-10.2011 Source

Neuroprotection by a mitochondria-targeted drug in a Parkinson's disease model. Ghosh A et al. Free Radical Biology and Medicine. 2010DOI: 10.1016/j.freeradbiomed.2010.08.028 Source

Mitochondria-Targeted Antioxidants Protect Against Amyloid-β Toxicity in Alzheimer's Disease Neurons. Manczak M et al. Journal of Alzheimer’s Disease. 2010DOI: 10.3233/JAD-2010-100564 Source

Mitochondrial Dysfunction in SOD1G93A-Bearing Astrocytes Promotes Motor Neuron Degeneration: Prevention by Mitochondrial-Targeted Antioxidants. Cassina P et al. The Journal of Neuroscience. 2008DOI: 10.1523/JNEUROSCI.5308-07.2008 Source

Mitochondrial Superoxide Production and Nuclear Factor Erythroid 2-Related Factor 2 Activation in p75 Neurotrophin Receptor-Induced Motor Neuron Apoptosis. Pehar M et al. The Journal of Neuroscience. 2007DOI: 10.1523/JNEUROSCI.0823-07.2007 Source

Manganese potentiates lipopolysaccharide-induced expression of NOS2 in C6 glioma cells through mitochondrial-dependent activation of nuclear factor kappaB. Barhoumi R et al. Molecular Brain Research. 2004DOI: 10.1016/j.molbrainres.2003.12.009 Source

Oxidative stress-mediated mitochondrial fission promotes hepatic stellate cell activation via stimulating oxidative phosphorylation. Zhou et al. Cell Death & Disease. 2022DOI: 10.1038/s41419-022-05088-x Source

Down regulation of NDUFS1 is involved in the progression of parenteral-nutrition-associated liver disease by increasing Oxidative stress. Wan et al. The Journal of Nutritional Biochemistry. 2023DOI: 10.1016/j.jnutbio.2022.109221 Source

Low-Dose Acetylsalicylic Acid and Mitochondria-Targeted Antioxidant Mitoquinone Attenuate Non-Alcoholic Steatohepatitis in Mice. Turkseven et al. Antioxidants. 2023DOI: 10.3390/antiox12040971 Source

Mitoquinone protects against acetaminophen-induced liver injury in an FSP1-dependent and GPX4-independent manner. He et al. Toxicology and Applied Pharmacology. 2023DOI: 10.1016/j.taap.2023.116452 Source

Effect of mitoquinone on liver metabolism and steatosis in obese and diabetic rats. Fink et al. Pharmacology Research & Perspectives. 2021DOI: 10.1002/prp2.701 Source

The mitochondria-targeting antioxidant MitoQ alleviated lipopolysaccharide/ d-galactosamine-induced acute liver injury in mice. Hu et al. Immunology Letters. 2021DOI: 10.1016/j.imlet.2021.09.003 Source

Novel Anti-inflammatory Treatments in Cirrhosis. A Literature-Based Study. Kronborg et al. Frontiers in Medicine. 2021DOI: 10.3389/fmed.2021.718896 Source

The emerging significance of mitochondrial targeted strategies in NAFLD treatment. Zhang et al. Life Sciences. 2023DOI: 10.1016/j.lfs.2023.121943 Source

Mitochondria-targeted ubiquinone (MitoQ) enhances acetaldehyde clearance by reversing alcohol-induced posttranslational modification of aldehyde dehydrogenase 2: A molecular mechanism of protection against alcoholic liver disease. Hao L et al. Redox Biology. 2018DOI: 10.1016/j.redox.2017.11.005 Source

Therapeutic targeting of the mitochondrial reactive oxygen species engine prevents portal hypertension and hepatic fibrogenesis. Weiskirchen R. Liver International. 2017DOI: 10.1111/liv.13442 Source

Mitochondria-targeted antioxidant mitoquinone deactivates human and rat hepatic stellate cells and reduces portal hypertension in cirrhotic rats. Vilaseca M et al. Liver International. 2017DOI: 10.1111/liv.13436 Source

Mitochondrial ROS induced by chronic ethanol exposure promote hyper-activation of the NLRP3 inflammasome. Hoyt LR et al. Redox Biology. 2017DOI: 10.1016/j.redox.2017.04.020 Source

Mitochondrial reactive oxygen species generation triggers inflammatory response and tissue injury associated with hepatic ischemia–reperfusion: Therapeutic potential of mitochondrially targeted antioxidants. Mukhopadhyay P et al. Free Radical Biology and Medicine. 2012DOI: 10.1016/j.freeradbiomed.2012.05.036 Source

Mitochondrial-targeted ubiquinone alleviates concanavalin A-induced hepatitis via immune modulation. Desta YT et al. International Immunopharmacology. 2020DOI: 10.1016/j.intimp.2020.106518 Source

Mitochondria-targeted antioxidant mitoquinone attenuates liver inflammation and fibrosis in cirrhotic rats. Turkseven S et al. American Journal of Physiology – Gastrointestinal and Liver Physiology. 2019DOI: 10.1152/ajpgi.00135.2019 Source

A Mitochondrial Specific Antioxidant Reverses Metabolic Dysfunction and Fatty Liver Induced by Maternal Cigarette Smoke in Mice. Li G et al. Nutrients. 2019DOI: 10.3390/nu11071669 Source

The damage-associated molecular pattern HMGB1 is released early after clinical hepatic ischemia/reperfusion. van Golen RF et al. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2019DOI: 10.1016/j.bbadis.2019.01.014 Source

In cirrhotic rats, mitochondria-targeted antioxidant mitoquinone attenuates liver inflammation and fibrosis by modulating oxidative stress and mitophagy. Turkseven S et al. Journal of Hepatology. 2018DOI: 10.1016/S0168-8278(18)31178-4 Source

Wnt/β‐catenin/RAS signaling mediates age‐related renal fibrosis and is associated with mitochondrial dysfunction. Miao J et al. Aging Cell. 2019DOI: 10.1111/acel.13004 Source

Evaluation of a novel mitochondria‐targeted anti-­oxidant therapy for ischaemia-­reperfusion injury in renal transplantation. Hamed M. 2017Source

AMPK activation coupling SENP1-Sirt3 axis protects against acute kidney injury. Zhu M et al. Molecular Therapy: The Journal of the American Society of Gene Therapy. 2023DOI: 10.1016/j.ymthe.2023.08.014 Source

Micheliolide Attenuates Lipopolysaccharide-Induced Inflammation by Modulating the mROS/NF-κB/NLRP3 Axis in Renal Tubular Epithelial Cells43. Lei X et al. Mediators of Inflammation. 2020DOI: 10.1155/2020/3934769 Source

Effects of oxidative stress on hepatic encephalopathy pathogenesis in mice. Bai Y et al. Nature Communications. 2023DOI: 10.1038/s41467-023-40081-8 Source

Mitochondria-derived reactive oxygen species are involved in renal cell ferroptosis during lipopolysaccharide-induced acute kidney injury. Liang NN et al. International Immunopharmacology. 2022DOI: 10.1016/j.intimp.2022.108687 Source

Mitoquinone Protects Podocytes from Angiotensin II-Induced Mitochondrial Dysfunction and Injury via the Keap1-Nrf2 Signaling Pathway. Zhu Z et al. Oxidative Medicine and Cellular Longevity. 2021DOI: 10.1155/2021/1394486 Source

Tubular Mitochondrial Dysfunction, Oxidative Stress, and Progression of Chronic Kidney Disease. Fontecha-Barriuso M et al. Antioxidants. 2022DOI: 10.3390/antiox11071356 Source

Micheliolide Attenuates Lipopolysaccharide-Induced Inflammation by Modulating the mROS/NF-κB/NLRP3 Axis in Renal Tubular Epithelial Cells43. Lei X et al. Mediators of Inflammation. 2020DOI: 10.1155/2020/3934769 Source

DsbA-L deficiency exacerbates mitochondrial dysfunction of tubular cells in diabetic kidney disease. Gao P et al. Clinical Science (London, England: 1979). 2020DOI: 10.1042/CS20200005 Source

Reactive oxygen species promote tubular injury in diabetic nephropathy: The role of the mitochondrial ros-txnip-nlrp3 biological axis. Han Y et al. Redox Biology. 2018DOI: 10.1016/j.redox.2018.02.013 Source

Mitochondrial Abnormality Facilitates Cyst Formation in Autosomal Dominant Polycystic Kidney Disease. Ishimoto Y et al. Molecular and Cellular Biology. 2017DOI: 10.1128/MCB.00337-1 Source

The swan-neck lesion: proximal tubular adaptation to oxidative stress in nephropathic cystinosis. Galaretta CI et al. American Journal of Physiology – Renal Physiology. 2015DOI: 10.1152/ajprenal.00591.2014

Contribution of mitochondrial function to exercise-induced attenuation of renal dysfunction in spontaneously hypertensive rats. Gu Q et al. Molecular and Cellular Biochemistry. 2015DOI: 10.1007/s11010-015-2439-6 Source

Peroxynitrite induced mitochondrial biogenesis following MnSOD knockdown in normal rat kidney (NRK) cells. Marine A et al. Redox Biology. 2014DOI: 10.1016/j.redox.2014.01.014 Source

Preclinical evaluation of the mitochondria-targeted antioxidant mitoquinone to treat sepsis-induced acute kidney injury. Patil NK et al. Federation of American Societies of Experimental Biology. 2013DOI: 10.1096/fasebj.27.1_supplement.889.8 Source

MitoQ Blunts Mitochondrial and Renal Damage during Cold Preservation of Porcine Kidneys. Parajuli N et al. PLoS ONE. 2012DOI: 10.1371/journal.pone.0048590 Source

The mitochondria-targeted antioxidant mitoquinone protects against cold storage injury of renal tubular cells and rat kidneys. Mitchell T et al. The Journal of Pharmacology and Experimental Therapeutics. 2011DOI: 10.1124/jpet.110.176743 Source

Parkin regulates adiposity by coordinating mitophagy with mitochondrial biogenesis in white adipocytes. Moore TM et al. Nature Communications. 2022DOI: 10.1038/s41467-022-34468-2 Source

Fgr kinase is required for proinflammatory macrophage activation during diet-induced obesity. Acín-Pérez R et al. Nature Metabolism. 2020DOI: 10.1038/s42255-020-00273-8 Source

Cysteine 253 of UCP1 regulates energy expenditure and sex-dependent adipose tissue inflammation. Mills EL et al. Cell Metabolism. 2022DOI: 10.1016/j.cmet.2021.11.003 Source

Accelerating cryoprotectant diffusion kinetics improves cryopreservation of pancreatic islets. Dolezalova N et al. Scientific Reports. 2021DOI: 10.1038/s41598-021-89853-6 Source

CD74 ablation rescues type 2 diabetes mellitus-induced cardiac remodeling and contractile dysfunction through pyroptosis-evoked regulation of ferroptosis. Chen L et al. Pharmacological Research. 2022DOI: 10.1016/j.phrs.2022.106086 Source

Antioxidant Mitoquinone Alleviates Chronic Pancreatitis via Anti-Fibrotic and Antioxidant Effects. Li M et al. Journal of Inflammation Research. 2022DOI: 10.2147/JIR.S357394 Source

The Antioxidant Moiety of MitoQ Imparts Minimal Metabolic Effects in Adipose Tissue of High Fat Fed Mice. Bond S et al. Frontiers in Physiology. 2019DOI: 10.3389/fphys.2019.00543 Source

Chlamydia pneumoniae infection-induced endoplasmic reticulum stress causes fatty acid-binding protein 4 secretion in murine adipocytes. Walenna NF et al. Journal Biological Chemistry. 2020DOI: 10.1074/jbc.RA119.010683 Source

The role of mitochondrial oxidative stress in the metabolic alterations in diet-induced obesity in rats. Marin-Royo G et al. The Journal of the Federation of American Societies for Experimental Biology. 2019DOI: 10.1096/fj.201900347RR Source

Effect of a mitochondrial-targeted coenzyme Q analog on pancreatic β-cell function and energetics in high fat fed obese mice. Imai Y et al. Pharmacology Research & Perspectives. 2018DOI: 10.1002/prp2.393 Source

Metabolic effects of a mitochondrial-targeted coenzyme Q analog in high fat fed obese mice. Fink BD et al. Pharmacology Research & Perspectives. 2017DOI: 10.1002/prp2.301 Source

A mitochondrial-targeted ubiquinone modulates muscle lipid profile and improves mitochondrial respiration in obesogenic diet-fed rats. Coudray C et al. British Journal of Nutrition. 2016DOI: 10.1017/S0007114515005528 Source

The mitochondrial-targeted antioxidant, MitoQ, increases liver mitochondrial cardiolipin content in obesogenic diet-fed rats. Fouret G et al. Biochimica et Biophys Acta (BBA) - Bioenergetics. 2015DOI: 10.1016/j.bbabio.2015.05.019 Source

FFA-ROS-P53-mediated mitochondrial apoptosis contributes to reduction of osteoblastogenesis and bone mass in type 2 diabetes mellitus. Li J et al. Scientific Reports. 2015DOI: 10.1038/srep12724 Source

A Mitochondrial-Targeted Coenzyme Q Analog Prevents Weight Gain and Ameliorates Hepatic Dysfunction in High-Fat–Fed Mice. Fink BD et al. The Journal of Pharmacology and Experimental Therapeutics. 2014DOI: 10.1124/jpet.114.219329 Source

Tectorigenin Attenuates Palmitate-Induced Endothelial Insulin Resistance via Targeting ROS-Associated Inflammation and IRS-1 Pathway. Wang Q et al. PLoS One. 2013DOI: 10.1371/journal.pone.0066417 Source

Mitochondria-targeted Antioxidants Protect Pancreatic β-cells against Oxidative Stress and Improve Insulin Secretion in Glucotoxicity and Glucolipotoxicity. Lim S et al. Cellular Physiology and Biochemistry. 2011DOI: 10.1159/000335802 Source

Programmed NP Cell Death Induced by Mitochondrial ROS in a One-Strike Loading Disc Degeneration Organ Culture Model. Li, Bao-Liang et al. Oxidative Medicine and Cellular Longevity. 2021DOI: 10.1155/2021/5608133 Source

507 Late-Breaking: Heat Stress and Mitoq Supplementation Impact Skeletal Muscle Mitochondrial Capacities in Pigs. Wesolowski, Lauren T et al. Journal of Animal Science. 2021DOI: 10.1093/jas/skab235.371 Source

The mitochondria-targeted antioxidant MitoQ, attenuates exercise-induced mitochondrial DNA damage. Williamson, Josh et al. Redox Biology. 2020DOI: 10.1016/j.redox.2020.101673 Source

Mitochondria-targeted antioxidant supplementation improves 8 km time trial performance in middle-aged trained male cyclists. Broome, S. C. et al. Journal of the International Society of Sports Nutrition. 2021DOI: 10.1186/s12970-021-00454-0 Source

MitoQ supplementation improves oxygen uptake kinetic by reduced reactive oxygen species levels and altered expression of miR-155 and miR-181b. Park, Yoonjung et al. The FASEB Journal. 2022DOI: 10.1096/fasebj.2022.36.S1.R6226 Source

MitoQ supplementation augments acute exercise-induced increases in muscle PGC1α mRNA and improves training-induced increases in peak power independent of mitochondrial content and function in untrained middle-aged men. Broome, S. C. et al. Redox Biology 2022DOI: 10.1016/j.redox.2022.102341 Source

MitoQ and CoQ10 supplementation mildly suppresses skeletal muscle mitochondrial hydrogen peroxide levels without impacting mitochondrial function in middle-aged men. Pham T et al. European Journal of Applied Physiology. 2020DOI: 10.1007/s00421-020-04396-4 Source

Myocardial NADPH oxidase-4 regulates the physiological response to acute exercise. Hancock M et al. Elife. 2018DOI: 10.7554/eLife.41044 Source

MitoQ Supplementation Improves Leg-Extension Power in Healthy Late Middle-Aged and Older Adults. Bispham NZ et al. The Journal of the Federation of American Societies for Experimental Biology. 2017DOI: 10.1096/fasebj.31.1_supplement.lb852 Source

MitoQ supplementation improves motor function and muscle mitochondrial health in old male mice. Jusice JN et al. Gerontologist 2015;55(2):163DOI: 10.1093/geront/gnv535.02 Source

The mitochondria targeted antioxidant MitoQ protects against fluoroquinolone-induced oxidative stress and mitochondrial membrane damage in human Achilles tendon cells. Lowes DA et al. Free Radical Research. 2009DOI: 10.1080/10715760902736275 Source

Mitochondria-targeted antioxidant MitoQ ameliorates ROS production and improves cell viability in cryopreserved buffalo fibroblasts. Punetha, Meeti et al. Tissue and Cell. 2023DOI: 10.1016/j.tice.2023.102067 Source

Mitochondrial Activity Is Upregulated in Nonlesional Atopic Dermatitis and Amenable to Therapeutic Intervention. Leman, Geraldine et al. Journal of Investigative Dermatology. 2022DOI: 10.1016/j.jid.2022.01.035 Source

Senescent human melanocytes drive skin ageing via paracrine telomere dysfunction. Victorelli S et al. The EMBO Journal. 2019DOI: 10.15252/embj.2019101982 Source

Protective effect of mitochondrially targeted antioxidant MitoQ on oxidatively stressed fibroblasts. Valachová K et al. L. Chemical Paper. 2018DOI: 10.1007/s11696-017-0359-5 Source

Collagen Fragmentation Promotes Oxidative Stress and Elevates Matrix Metalloproteinase-1 in Fibroblasts in Aged Human Skin. Fisher GJ et al. The American Journal of Pathology. 2009DOI: 10.2353/ajpath.2009.080599 Source

Cellular response to infrared radiation involves retrograde mitochondrial signaling. Schroeder P et al. Free Radical Biology and Medicine. 2007DOI: 10.1016/j.freeradbiomed.2007.04.002 Source

7-Dehydrocholesterol enhances ultraviolet A-induced oxidative stress in keratinocytes: Roles of NADPH oxidase, mitochondria, and lipid rafts. Valencia A et al. Free Radical Biology and Medicine. 2006DOI: 10.1016/j.freeradbiomed.2006.09.006 Source

MitoQ counteracts telomere shortening and elongates lifespan of fibroblasts under mild oxidative stress. Saretzki G et al. Aging Cell. 2003DOI: 10.1046/j.1474-9728.2003.00040.x Source

The mitochondrial gene-CMPK2 functions as a rheostat for macrophage homeostasis. Arumugam, Prabhakar et al. Frontiers in Immunology. 2022DOI: 10.3389/fimmu.2022.935710 Source

Tumor Microenvironment following Gemcitabine Treatment Favors Differentiation of Immunosuppressive Ly6Chigh Myeloid Cells. Wu, Caijun et al. The Journal of Immunology. 2020DOI: 10.4049/jimmunol.1900930 Source

Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1α/Glycolysis-Dependent Axis. Codo, Ana Campos et al. Cell Metabolism. 2020DOI: 10.1016/j.cmet.2020.07.007 Souce

Mitochondrial reactive oxygen is critical for IL-12/IL-18-induced IFN-γ production by CD4+ T cells and is regulated by Fas/FasL signaling. Rackov, Gorjana et al. Cell Death & Disease. 2022DOI: 10.1038/s41419-022-04907-5 Source

DMGV Is a Rheostat of T Cell Survival and a Potential Therapeutic for Inflammatory Diseases and Cancers. Yang, Fengyuan Mandy et al. Frontiers in Immunology. 2022DOI: 10.3389/fimmu.2022.918241 Source

Mitoquinone Mesylate and Mitochondrial DNA in End Organs in Humanized Mouse Model of Chronic Treated Human Immunodeficiency Virus Infection. Song, Sihyeong et al. The Journal of Infectious Diseases. 2023DOI: 10.1093/infdis/jiad044 Source

Mitochondrial Reactive Oxygen Species Are Essential for the Development of Psoriatic Inflammation. Mizuguchi, Soichi et al. Frontiers in Immunology. 2021DOI: 10.3389/fimmu.2021.714897 Source

Obesity Exacerbates Coxsackievirus Infection via Lipid-Induced Mitochondrial Reactive Oxygen Species Generation. Kim, Seong-Ryeol et al. Immune Network. 2022DOI: 10.4110/in.2022.22.e19 Source

Mitochondrial Antioxidants Alleviate Oxidative and Nitrosative Stress in a Cellular Model of Sepsis. Apostolova N et al. Pharmaceutical Research. 2011DOI: 10.1007/s11095-011-0528-0 Source

An investigation of the effects of MitoQ on human peripheral mononuclear cells. Marthandan S et al. Free Radical Research. 2011DOI: 10.3109/10715762.2010.532497 Source

Tempol, an Intracellular Antioxidant, Inhibits Tissue Factor Expression, Attenuates Dendritic Cell Function, and Is Partially Protective in a Murine Model of Cerebral Malaria. Francischetti IM et al. PLoS One. 2014DOI: 10.1371/journal.pone.0087140 Source

Antioxidants that protect mitochondria reduce interleukin-6 and oxidative stress, improve mitochondrial function, and reduce biochemical markers of organ dysfunction in a rat model of acute sepsis. Lowes DA et al. British Journal of Anaesthesia. 2013DOI: 10.1093/bja/aes577 Source

Mitochondrial anti-oxidant protects IEX-1 deficient mice from organ damage during endotoxemia. Ramsey H et al. International Immunopharmacology. 2014DOI: 0.1016/j.intimp.2014.10.019 Source

FRI0242 Role of Mitochondria- and Nadph Oxidase-Derived ROS in Fibroblasts Isolated from Patients Affected by Systemic Sclerosis. Spadoni T et al. Annals of the Rheumatic Diseases. 2016DOI: 10.1136/annrheumdis-2016-eular.3908 Source

IL-4 Protects the Mitochondria Against TNFα and IFNγ Induced Insult During Clearance of Infection with Citrobacter rodentium and Escherichia coli. Maiti AK et al. Scientific Reports. 2015DOI: 10.1038/srep15434 Source

Targeting mitochondrial dysfunction can restore antiviral activity of exhausted HBV-specific CD8 T cells in chronic hepatitis B. Fisicaro P et al. Nature Medicine. 2017DOI: 10.1038/nm.4275 Source

P037 MDR1-deficiency unmasks mitochondrial dysfunction as a pathogenic mechanism in IBD. Ho GT et al. Journal of Crohn’s and Colitis. 2017DOI: 10.1093/ecco-jcc/jjx002.163 Source

Reactive oxygen species induce virus-independent MAVS oligomerization in systemic lupus erythematosus. Buskiewicz IA et al. Science Signaling. 2016DOI: 10.1126/scisignal.aaf1933 Source

Detection of a microbial metabolite by STING regulates inflammasome activation in response to Chlamydia trachomatis infection. Webster SJ et al. PLoS Pathogens. 2017DOI: 10.1371/journal.ppat.1006383 Source

Deficiency in Duox2 activity alleviates ileitis in GPx1- and GPx2-knockout mice without affecting apoptosis incidence in the crypt epithelium. Chu F-F et al. Redox Biology. 2017DOI: 10.1016/j.redox.2016.11.001 Source

The mitochondrially targeted antioxidant MitoQ protects the intestinal barrier by ameliorating mitochondrial DNA damage via the Nrf2/ARE signaling pathway. Hu Q et al. Cell Death & Disease. 2018DOI: 10.1038/s41419-018-0436-x Source

MDR1 deficiency impairs mitochondrial homeostasis and promotes intestinal inflammation. Ho GT et al. Mucosal Immunology. 2018DOI: 10.1038/mi.2017.31 Source

Direct and indirect pro-inflammatory cytokine response resulting from TC-83 infection of glial cells. Keck F et al. Virulence. 2018DOI: 10.1080/21505594.2018.1509668 Source

Mitochondrial-Directed Antioxidant Reduces Microglial-Induced Inflammation in Murine In Vitro Model of TC-83 Infection. Keck F et al. Viruses. 2018DOI: 10.3390/v10110606 Source

MitoQ Modulates Lipopolysaccharide-Induced Intestinal Barrier Dysfunction via Regulating Nrf2 Signaling. Zhang et al. Mediators of Inflammation. 2020DOI: 10.1155/2020/3276148 Source

The Reduced Oligomerization of MAVS Mediated by ROS Enhances the Cellular Radioresistance. Du Y et al. Oxidative Medicine and Cellular Longevity. 2020 March 4DOI: 10.1155/2020/2167129 Source

Human microvascular dysfunction and apoptotic injury induced by AL amyloidosis light chain proteins. Migrino RQ et al. American Journal of Physiology-Heart and Circulatory Physiology. 2011DOI: 10.1152/ajpheart.00503.2011 Source

Misfolding of short-chain acyl-CoA dehydrogenase leads to mitochondrial fission and oxidative stress. Schmidt SP et al. Molecular Genetics and Metabolism. 2010DOI: 10.1016/j.ymgme.2010.03.009 Source

Mitochondria-targeted antioxidants protect Friedreich Ataxia fibroblasts from endogenous oxidative stress more effectively than untargeted antioxidants. Jauslin ML et al. The Journal of the Federation of American Societies for Experimental Biology. 2003DOI: 10.1096/fj.03-0240fje Source

The Activity of Menkes Disease Protein ATP7A Is Essential for Redox Balance in Mitochondria *. Bhattacharjee A et al. Journal of Biological Chemistry. 2016DOI: 10.1074/jbc.M116.727248 Source

Mitochondrial Superoxide Contributes to Hippocampal Synaptic Dysfunction and Memory Deficits in Angelman Syndrome Model Mice. Santini E et al. The Journal of Neuroscience. 2015DOI: 10.1523/JNEUROSCI.2246-15.2015 Source

Antioxidants successfully reduce ROS production in propionic acidemia fibroblasts. Gallego-Villar L et al. Biochemical and Biophysical Research Communications. 2014DOI: 10.1016/j.bbrc.2014.08.091 Source

Treatment with antioxidants ameliorates oxidative damage in a mouse model of propionic acidemia. Rivera-Barahona A et al. Molecular Genetics and Metabolism. 2017DOI: 10.1016/j.ymgme.2017.07.009 Source

Mitochondrial ROS in Slc4a11 KO Corneal Endothelial Cells Lead to ER Stress. Shyam, Rajalekshmy et al. Frontiers in Cell and Developmental Biology. 2022DOI: 10.3389/fcell.2022.878395 Source

MitoROS due to loss of Slc4a11 in corneal endothelial cells induces ER stress, lysosomal dysfunction and impairs autophagy. Shyam, Rajalekshmy et al. 2020DOI: 10.1101/2020.08.27.250977 Source

Mitochondrial ROS Induced Lysosomal Dysfunction and Autophagy Impairment in an Animal Model of Congenital Hereditary Endothelial Dystrophy. Shyam, Rajalekshmy et al. Investigative Ophthalmology & Visual Science. 2021DOI: 10.1167/iovs.62.12.15 Source

Mitoquinone intravitreal injection ameliorates retinal ischemia-reperfusion injury in rats involving SIRT1/Notch1/NADPH axis. D, Tang et al. Drug development research. 2022DOI: 10.1002/ddr.21911 Source

Mitochondrial-Targeted Antioxidants Attenuate TGF-β2 Signaling in Human Trabecular Meshwork Cells. Rao VR et al. Investigative Ophthalmology & Visual Science. 2019DOI: 10.1167/iovs.19-27542 Source

Regulatory effect of mitoQ on the mtROS-NLRP3 inflammasome pathway in leptin-pretreated BEAS-2 cells. Chong, Lei et al. Experimental and Therapeutic Medicine. 2021.DOI: 10.3892/etm.2021.9897 Source

[Mitochondrial coenzyme Q attenuates lipopolysaccharide-induced mitochondria-dependent apoptosis in type II alveolar epithelial cells via phosphatidylinositol 3-kinase/Akt pathway]. Zhou, Jiaqi et al. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2022.DOI: 10.3760/cma.j.cn121430-20211221-01899 Source

Mitoquinone mitigates paraquat-induced A549 lung epithelial cell injury by promoting MFN1/MFN2-mediated mitochondrial fusion. Liu, Chao et al. Journal of Biochemical and Molecular Toxicology. 2022.DOI: 10.1002/jbt.23127 Source

Mitochondrial Coenzyme Q Protects Sepsis-Induced Acute Lung Injury by Activating PI3K/Akt/GSK-3<i>β</i>/mTOR Pathway in Rats. Li, Ruirui et al. BioMed Research International. 2019.DOI: 10.1155/2019/5240898 Source

Decreased IDO1 Dependent Tryptophan Metabolism in Aged Lung during Influenza. Cho, Soo Jung et al. The European respiratory journal. 2021.DOI: 10.1183/13993003.00443-2020 Source

Maternal Particulate Matter Exposure Impairs Lung Health and Is Associated with Mitochondrial Damage. Wang, Baoming et al. Antioxidants. 2021.DOI: 10.3390/antiox10071029 Source

SIRT1 prevents cigarette smoking-induced lung fibroblasts activation by regulating mitochondrial oxidative stress and lipid metabolism. Zhang, Yue et al. Journal of Translational Medicine. 2022.DOI: 10.1186/s12967-022-03408-5 Source

Arsenic induces ferroptosis and acute lung injury through mtROS-mediated mitochondria-associated endoplasmic reticulum membrane dysfunction. Li, Meng-Die et al. Ecotoxicology and Environmental Safety. 2022.DOI: 10.1016/j.ecoenv.2022.113595 Source

Diesel exhaust particles distort lung epithelial progenitors and their fibroblast niche. Wu, Xinhui et al. Environmental Pollution. 2022.DOI: 10.1016/j.envpol.2022.119292 Source

Antioxidant mitoquinone ameliorates EtOH-LPS induced lung injury by inhibiting mitophagy and NLRP3 inflammasome activation. Sang, Wenhua et al. Frontiers in Immunology. 2022.DOI: 10.3389/fimmu.2022.973108 Source

Mitoquinone mesylate attenuates pathological features of lean and obese allergic asthma in mice. Chandrasekaran, Ravishankar et al. American Journal of Physiology-Lung Cellular and Molecular Physiology. 2023.DOI: 10.1152/ajplung.00249.2022 Source

Mitoquinone mesylate targets SARS-CoV-2 and associated lung inflammation through host pathways. Petcherski, Anton et al. bioRxiv (preprint). 2015DOI: 10.1101/2022.02.22.481100 Source

Mitochondrial-Targeted Antioxidant Therapy Decreases Transforming Growth Factor-β–Mediated Collagen Production in a Murine Asthma Model. Jaffer OA et al. American Journal of Respiratory Cell and Molecular Biology. 2015DOI: 10.1165/rcmb.2013-0519OC Source

Oxidative stress–induced mitochondrial dysfunction drives inflammation and airway smooth muscle remodeling in patients with chronic obstructive pulmonary disease. Wiegman CH et al. The Journal of Allergy and Clinical Immunology. 2015DOI: 10.1016/j.jaci.2015.01.046 Source

Antioxidant mitoquinone suppresses benign prostatic hyperplasia by regulating the AR–NLRP3 pathway. Jin, Bo-Ram et al. Redox Biology. 2023.DOI: 10.1016/j.redox.2023.102816 Source

Hypoxia-induced mitochondrial abnormalities in cells of the placenta. Vangrieken, Philippe et al. PLOS ONE. 2021.DOI: 10.1371/journal.pone.0245155 Source

Comparative evidence support better antioxidant efficacy of mitochondrial-targeted (Mitoquinone) than cytosolic (Resveratrol) antioxidant in improving in-vitro sperm functions of cryopreserved buffalo (Bubalus bubalis) semen. Tiwari, S et al. Cryobiology. 2021.DOI: 10.1016/j.cryobiol.2021.04.007 Source

Effect of mitochondria-targeted antioxidant on the regulation of the mitochondrial function of sperm during cryopreservation. Arjun, Venkateshappa et al. Andrologia. 2022.DOI: 10.1111/and.14431 Source

Restoring Sperm Quality Post-Cryopreservation Using Mitochondrial-Targeted Compounds. Gonzalez, Macarena et al. Antioxidants. 2022.DOI: 10.3390/antiox11091808 Source

Effects of mitoquinone (MitoQ) supplementation during boar semen cryopreservation on sperm quality, antioxidant status and mitochondrial proteomics. Shi, Lei et al. Animal Reproduction Science. 2022.DOI: 10.1016/j.anireprosci.2022.107099 Source

Does Antioxidant Mitoquinone (MitoQ) Ameliorate Oxidative Stress in Frozen–Thawed Rooster Sperm?. Sun, Lingwei et al. Animals. 2022.DOI: 10.3390/ani12223181 Source

Mitochondria-targeted antioxidant “MitoQ” improves rooster's cooled sperm quality indicators and reproductive performance. Alipour-Jenaghard, P. et al. Theriogenology. 2023.DOI: 10.1016/j.theriogenology.2022.11.034 Source

Protective effects of different doses of MitoQ separately and combined with trehalose on oxidative stress and sperm function of cryopreserved Markhoz goat semen. Rezaei, Ako et al. Cryobiology. 2023.DOI: 10.1016/j.cryobiol.2022.12.019 Source

MitoQ Protects Ovarian Organoids against Oxidative Stress during Oogenesis and Folliculogenesis In Vitro. Wang, Jiapeng et al. International Journal of Molecular Sciences. 2023.DOI: 10.3390/ijms24020924 Source

Comparison of the performance of targeted mitochondrial antioxidant mitoquinone and non-targeted antioxidant pentoxifylline in improving rooster sperm parameters during freezing and thawing. Nazari, Mahdi et al. Poultry Science. 2022.DOI: 10.1016/j.psj.2022.102035 Source

Preservation of the quality and fertility potential of post-thawed rooster sperm using MitoQ. Alipour-Jenaghard, P. et al. Theriogenology. 2023.DOI: 10.1016/j.theriogenology.2023.06.014 Source

The mitochondria-targeted antioxidant “MitoQ” preserves quality and reproductive performance of ram spermatozoa cryopreserved in soybean lecithin-based extender. Javaheri Barfourooshi, Hoda et al. Theriogenology. 2023.DOI: 10.1016/j.theriogenology.2023.05.032 Source

Nanoparticle‐encapsulated antioxidant improves placental mitochondrial function in a sexually dimorphic manner in a rat model of prenatal hypoxia. Ganguly, Esha; Kirschenman, Raven. 2023.DOI: 10.1096/fj.202002193R Source

Effect of Thawing Rates and Antioxidants on Semen Cryopreservation in Hu Sheep. Wu, Caifeng et al. Biopreservation and Biobanking. 2021.DOI: 10.1089/bio.2020.0067 Source

Placental treatment improves cardiac tolerance to ischemia/reperfusion insult in adult male and female offspring exposed to prenatal hypoxia. Hula, Nataliia et al. Pharmacological Research. 2021.DOI: 10.1016/j.phrs.2021.105461 Source

Mitochondria antioxidant protection against cardiovascular dysfunction programmed by early-onset gestational hypoxia. Spiroski, Ana-Mishel et al. FASEB journal: official publication of the Federation of American Societies for Experimental Biology. 021.DOI: 10.1096/fj.202002705R Source

Systemic delivery of a mitochondria targeted antioxidant partially preserves limb muscle mass and grip strength in response to androgen deprivation. Rossetti, Michael L. et al. Molecular and Cellular Endocrinology. 2021.DOI: 10.1016/j.mce.2021.111391 Source

Mitoquinone rescues stress induced mitophagy in aged oocytes. Khan, Shaihla A. et al. Fertility and Sterility. 2021.DOI: 10.1016/j.fertnstert.2021.07.011 Source

Noninvasive Biomarkers for Cardiovascular Dysfunction Programmed in Male Offspring of Adverse Pregnancy. Lakshman, Rama et al. Hypertension (Dallas, Tex. : 1979). 2021.DOI: 10.1161/HYPERTENSIONAHA.121.17926 Source

Mitochondrial ROS-mediated ribosome stalling and GCN2 activation are partially involved in 1-nitropyrene-induced steroidogenic inhibition in testes. Li, Jian et al. Environment International. 2022.DOI: 10.1016/j.envint.2022.107393 Source

Mito-Q promotes porcine oocytes maturation by maintaining mitochondrial thermogenesis via UCP2 downregulation. Zhou, Dan et al. Theriogenology. 2022.DOI: 10.1016/j.theriogenology.2022.05.006 Source

Mitoquinone shifts energy metabolism to reduce ROS-induced oxeiptosis in female granulosa cells and mouse oocytes. Tsui, Kuan-Hao; Li, Chia-Jung. Aging. 2023.DOI: 10.18632/aging.204475 Source

Control of mitochondrial integrity influences oocyte quality during reproductive aging. Khan, Shaihla A et al. Molecular Human Reproduction. 2023.DOI: 10.1093/molehr/gaad028 Source

Translatable mitochondria-targeted protection against programmed cardiovascular dysfunction. Botting, K. J. et al. Science Advances. 2020.DOI: 10.1126/sciadv.abb1929 Source

Mitochondria-targeted therapeutics, MitoQ and BGP-15, reverse aging-associated meiotic spindle defects in mouse and human oocytes. Al-Zubaidi, Usama et al. Human Reproduction. 2021.DOI: 10.1093/humrep/deaa300 Source

Assessment of Mitochondrial Function and Developmental Potential of Mouse Oocytes after Mitoquinone Supplementation during Vitrification. Shirzeyli, Maryam H et al. Journal of the American Association for Laboratory Animal Science. 2021.DOI: 10.30802/AALAS-JAALAS-20-000123 Source

Unraveling Subcellular and Ultrastructural Changes During Vitrification of Human Spermatozoa: Effect of a Mitochondria-Targeted Antioxidant and a Permeable Cryoprotectant. Kumar, Pradeep et al. Frontiers in Cell and Developmental Biology. 2021.DOI: 10.3389/fcell.2021.672862 Source

Female reproductive life span is extended by targeted removal of fibrotic collagen from the mouse ovary. Umehara, Takashi et al. Science Advances. 2022.DOI: 10.1126/sciadv.abn4564 Source

Mitochondria-targeted antioxidant mitoquinone protects post-thaw human sperm against oxidative stress injury. Liu L et al. Zhonghua Nan Ke Xue. 2016;22(3):205-11Source

Inhibition of ROS production through mitochondria-targeted antioxidant and mitochondrial uncoupling increases post-thaw sperm viability in yellow catfish. Fang L et al. Cryobiology. 2014DOI: 10.1016/j.cryobiol.2014.09.005 Source

MitoQ supplementation prevent long-term impact of maternal smoking on renal development, oxidative stress and mitochondrial density in male mice offspring. Sukjamnong S et al. Scientific Reports. 2018DOI: 10.1038/s41598-018-24949-0 Source

Treating the placenta to prevent adverse effects of gestational hypoxia on fetal brain development. Phillips TJ et al. Scientific Reports. 2017DOI: 10.1038/s41598-017-06300-1 Source

Effect of long-term maternal smoking on the offspring’s lung health. Sukjamnong S et al. American Journal of Physiology-Lung Cellular and Molecular Physiology. 2017DOI: 10.1152/ajplung.00134.2017 Source

Mitochondria-targeted antioxidant therapy for an animal model of PCOS-IR. Ding Y et al. International Journal of Molecular Medicine. 2018DOI: 10.3892/ijmm.2018.3977 Source

Placental Adaptation to Early-Onset Hypoxic Pregnancy and Mitochondria-Targeted Antioxidant Therapy in a Rodent Model. Nuzzo AM et al. The American Journal of Pathology. 2018DOI: 10.1016/j.ajpath.2018.07.027 Source

Role of Mitochondrial Dysfunction and Reactive Oxygen Species in Mediating Hypertension in the Reduced Uterine Perfusion Pressure Rat Model of Preeclampsia. Vaka VR et al. Hypertension. 2018DOI: 10.1161/HYPERTENSIONAHA.118.11290 Source

Sex-Specific Effects of Nanoparticle-Encapsulated MitoQ (nMitoQ) Delivery to the Placenta in a Rat Model of Fetal Hypoxia. Ganguly E et al. Frontiers in Physiology. 2019DOI: 10.3389/fphys.2019.00562 Source

Exposing Mouse Oocytes to MitoQ During In Vitro Maturation Improves Maturation and Developmental Competence. Hosseinzadeh Shirzeyli M et al. Iranian Journal of Biotechnology. 2019DOI: 10.30498/IJB.2020.154641.2454 Source

Mitochondria-targeted therapy rescues development and quality of embryos derived from oocytes matured under oxidative stress conditions: a bovine in vitro model. Marei W et al. Human Reproduction. 2019DOI: 10.1093/humrep/dez161 Source

Microbe-derived antioxidants attenuate cobalt chloride-induced mitochondrial function, autophagy and BNIP3-dependent mitophagy pathways in BRL3A cells. Luo, Zhen et al. Ecotoxicology and Environmental Safety. 2022.DOI: 10.1016/j.ecoenv.2022.113219 Source

Iron-Dependent Mitochondrial Dysfunction Contributes to the Pathogenesis of Pulmonary Fibrosis. Takahashi, Mai et al. Frontiers in Pharmacology. 2022.DOI: 10.3389/fphar.2021.643980 Source

Ultrafine black carbon caused mitochondrial oxidative stress, mitochondrial dysfunction and mitophagy in SH-SY5Y cells. Shang, Yu et al. Science of The Total Environment. 2022.DOI: 10.1016/j.scitotenv.2021.151899 Source

Local production of reactive oxygen species drives vincristine-induced axon degeneration. Gómez-Deza, Jorge et al. bioRxiv (preprint). 2023.DOI: 10.1101/2022.07.30.501173 Source

Cobalt nanoparticles induce mitochondrial damage and β-amyloid toxicity via the generation of reactive oxygen species. Chen, Jingrong et al. NeuroToxicology. 2023DOI: 10.1016/j.neuro.2023.01.010 Source

Epothilone B inactivation of Sirtuin1 promotes mitochondrial reactive oxygen species to induce dysfunction and ferroptosis of Schwann cells. Liang, Zhuowen et al. European Journal of Pharmaceutical Sciences. 2023.DOI: 10.1016/j.ejps.2022.106350 Source

Mitoquinone alleviates bleomycin-induced acute lung injury via inhibiting mitochondrial ROS-dependent pulmonary epithelial ferroptosis. Zhan, Ping et al. International Immunopharmacology. 2022.DOI: 10.1016/j.intimp.2022.109359 Source

PM2.5 induces mitochondrial dysfunction via AHR-mediated cyp1a1 overexpression during zebrafish heart development. Chen, Jin et al. Toxicology. 2023DOI: 10.1016/j.tox.2023.153466 Source

Doxorubicin activates nuclear factor of activated T-lymphocytes and Fas ligand transcription: role of mitochondrial reactive oxygen species and calcium. Kalivendi SV et al. Biochemical Journal. 2005DOI: 10.1042/BJ20050285 Source

Mitochondrial impairment contributes to cocaine-induced cardiac dysfunction: Prevention by the targeted antioxidant MitoQ. Vergeade A et al. Free Radical Biology and Medicine. 2010DOI: 10.1016/j.freeradbiomed.2010.05.024 Source

Consequences of long-term oral administration of the mitochondria-targeted antioxidant MitoQ to wild-type mice. Rodriguez-Cuenca S et al. Free Radical Biology and Medicine. 2010DOI: 10.1016/j.freeradbiomed.2009.10.039 Source

Do Mitochondriotropic Antioxidants Prevent Chlorinative Stress-Induced Mitochondrial and Cellular Injury?. Whiteman M et al. Antioxidant & Redox Signaling. 2008DOI: 10.1089/ars.2007.1879 Source

Mitochondrial-targeted antioxidants represent a promising approach for prevention of cisplatin-induced nephropathy. Mukhopadhyay P et al. Free Radical and Medicine. 2012DOI: 10.1016/j.freeradbiomed.2011.11.001 Source

Prevention of gentamicin-induced apoptosis with the mitochondria-targeted antioxidant mitoquinone. Ojano-Dirain CP et al. Laryngoscope. 2012DOI: 10.1002/lary.23593 Source

Protective efficacy of mitochondrial targeted antioxidant MitoQ against dichlorvos induced oxidative stress and cell death in rat brain. Wani WY et al. Neuropharmacology. 2011DOI: 10.1016/j.neuropharm.2011.07.008 Source

Upregulation of autophagy decreases chlorine-induced mitochondrial injury and lung inflammation. Jurkuvenaite A et al. Free Radical Biology and Medicine. 2015DOI: 10.1016/j.freeradbiomed.2015.03.039 Source

Evaluation of Mitoquinone for Protecting Against Amikacin-Induced Ototoxicity in Guinea Pigs. Dirain CO et al. Otology & Neurotology. 2018DOI: 10.1097/MAO.0000000000001638 Source

Neuroprotective Efficacy of Mitochondrial Antioxidant MitoQ in Suppressing Peroxynitrite-Mediated Mitochondrial Dysfunction Inflicted by Lead Toxicity in the Rat Brain. Maiti AK et al. Neurotoxicity Research. 2017DOI: 10.1007/s12640-016-9692-7 Source

Mitochondria-Targeted Antioxidant Mitoquinone Reduces Cisplatin-Induced Ototoxicity in Guinea Pigs. Tate AD et al. Otolaryngology-Head and Neck Surgery. 2017DOI: 10.1177/0194599816678381 Source

Skeletal muscle atrophy and dysfunction in breast cancer patients: role for chemotherapy-derived oxidant stress. Guigni BA et al. American Journal of Physiology-Cell Physiology. 2018DOI: 10.1152/ajpcell.00002.2018 Source

Ubiquitination and receptor-mediated mitophagy converge to eliminate oxidation-damaged mitochondria during hypoxia. Sulkshane, Prasad et al. Redox Biology. 2021.DOI: 10.1016/j.redox.2021.102047 Source

Detection of 8-oxoguanine and apurinic/apyrimidinic sites using a fluorophore-labeled probe with cell-penetrating ability. Kang, Dong Min et al. BMC Molecular and Cell Biology. 2019.DOI: 10.1186/s12860-019-0236-x Source

NDP52 acts as a redox sensor in PINK1/Parkin-mediated mitophagy. Kataura, Tetsushi et al. The EMBO Journal. 2023.DOI: 10.15252/embj.2022111372 Source

Mitochondria-Targeted Antioxidant Mitoquinone Maintains Mitochondrial Homeostasis through the Sirt3-Dependent Pathway to Mitigate Oxidative Damage Caused by Renal Ischemia/Reperfusion. Mao, Hu et al. Oxidative Medicine and Cellular Longevity. 2022.DOI: 10.1155/2022/2213503 Source

Redox-regulation and life-history trade-offs: scavenging mitochondrial ROS improves growth in a wild bird. Velando, Alberto et al. Scientific Reports. 2019.DOI: 10.1038/s41598-019-38535-5 Source

Superoxide Activates Mitochondrial Uncoupling Protein 2 from the Matrix Side: STUDIES USING TARGETED ANTIOXIDANTS *. Echtay KS et al. Journal of Biological Chemistry. 2002DOI: 10.1074/jbc.M208262200 Source

Supplementation of Endothelial Cells with Mitochondria-targeted Antioxidants Inhibit Peroxide-induced Mitochondrial Iron Uptake, Oxidative Damage, and Apoptosis *. Dhanasekaran A et al. Journal of Biological Chemistry. 2004DOI: 10.1074/jbc.M404003200 Source

Role of Redox Signaling in the Autonomous Proliferative Response of Endothelial Cells to Hypoxia. Schäfer M et al. Circulation Research. 2003DOI: 10.1161/01.RES.0000070882.81508.FC Source

Redox Regulation of cAMP-responsive Element-binding Protein and Induction of Manganous Superoxide Dismutase in Nerve Growth Factor-dependent Cell Survival *. Bedogni B et al. Journal of Biological Chemistry. 2003DOI: 10.1074/jbc.M301089200 Source

Interactions of Mitochondria-targeted and Untargeted Ubiquinones with the Mitochondrial Respiratory Chain and Reactive Oxygen Species: IMPLICATIONS FOR THE USE OF EXOGENOUS UBIQUINONES AS THERAPIES AND EXPERIMENTAL TOOLS *♦. James AM et al. Journal of Biological Chemistry. 2005DOI: 10.1074/jbc.M501527200 Source

Protective role of MnSOD and redox regulation of neuronal cell survival. Galeotti T et al. Biomedicine & Pharmacotherapy. 2005DOI: 10.1016/j.biopha.2005.03.002 Source

OxLDL enhances L-type Ca2+ currents via lysophosphatidylcholine-induced mitochondrial reactive oxygen species (ROS) production. Fearon IM. Cardiovascular Research. 2006DOI: 10.1016/j.cardiores.2005.11.019 Source

Hydrogen peroxide produced inside mitochondria takes part in cell-to-cell transmission of apoptotic signal. Pletjushkina OY et al. Biochemistry (Moscow). 2006DOI: 10.1134/S0006297906010093 Source

Long-distance apoptotic killing of cells is mediated by hydrogen peroxide in a mitochondrial ROS-dependent fashion. Pletjushkina OY et al. Cell Death & Differentiation. 2005DOI: 10.1038/sj.cdd.4401685 Source

Inhibition of complex I of the electron transport chain causes O2−·-mediated mitochondrial outgrowth. Koopman WJ et al. Cellular Metabolism. 2005DOI: 10.1152/ajpcell.00607.2004 Source

Respiratory chain deficiency slows down cell-cycle progression via reduced ROS generation and is associated with a reduction of p21CIP1/WAF1. Schauen M et al. Journal ofDOI: 10.1002/jcp.20711 Source

Production of reactive oxygen species in mitochondria of HeLa cells under oxidative stress. Chernyak BV et al. Biochimica et Biophysica Acta (BBA) – Bioenergetics . 2006DOI: 10.1016/j.bbabio.2006.02.019 Source

Flow Dilation in Rat Small Mesenteric Arteries is Mediated by Hydrogen Peroxide Generated from CYP Epoxygenases and Xanthine Oxidase. Ngai CY. The Open Circulation and Vascular Journal. 2009DOI: 10.2174/1877382600902010015 Source

TNFα-induced lysosomal membrane permeability is downstream of MOMP and triggered by caspase-mediated NDUFS1 cleavage and ROS formation. Huai J et al. Journal of Cell Science. 2013DOI: 10.1242/jcs.129999 Source

Role of mitochondrial reactive oxygen species in osteoclast differentiation. Srinivasan S et al. Annals of the New York Academy of Sciences. 2010DOI: 10.1111/j.1749-6632.2009.05377.x Source

mtDNA T8993G Mutation-Induced F1F0-ATP Synthase Defect Augments Mitochondrial Dysfunction Associated with hypoxia/reoxygenation: The Protective Role of Melatonin. Huang W-Y et al. PLoS One. 2013DOI: 10.1371/journal.pone.0081546 Source

Differential modulation of ROS signals and other mitochondrial parameters by the antioxidants MitoQ, resveratrol and curcumin in human adipocytes. Hirzel E et al. Journal of Receptors and Signal Transduction. 2013DOI: 10.3109/10799893.2013.822887 Source

Mitochondria-targeted molecules determine the redness of the zebra finch bill. Cantarero A et al. Biology Letters. 2017DOI: 10.1098/rsbl.2017.0455 Source

Reactive oxygen species derived from NADPH oxidase 1 and mitochondria mediate angiotensin II-induced smooth muscle cell senescence. Tsai IC et al. Journal of Molecular and Cellular Cardiology. 2016DOI: 10.1016/j.yjmcc.2016.07.001 Source

Ammonia sensitive SLC4A11 mitochondrial uncoupling reduces glutamine induced oxidative stress. Ogando DG et al. Redox Biology. 2019DOI: 10.1016/j.redox.2019.101260 Source

Premature synaptic mitochondrial dysfunction in the hippocampus during aging contributes to memory loss. Olesen M et al. Redox Biology. 2020DOI: 10.1016/j.redox.2020.101558 Source

The role of docosahexaenoic acid in mediating mitochondrial membrane lipid oxidation and apoptosis in colonocytes. Ng, Yeevoon et al. Carcinogenesis. 2005.DOI: 10.1093/carcin/bgi163 Source

Targeting glutamine utilization to block metabolic adaptation of tumor cells under the stress of carboxyamidotriazole-induced nutrients unavailability. Shi, Jing et al. Acta Pharmaceutica Sinica. B. 2022.DOI: 10.1016/j.apsb.2021.07.008 Source

HDAC class I inhibitor domatinostat sensitizes pancreatic cancer to chemotherapy by targeting cancer stem cell compartment via FOXM1 modulation. Roca, Maria Serena et al. Journal of Experimental & Clinical Cancer Research. 2022.DOI: 10.1186/s13046-022-02295-4 Source

The Antioxidant Transcription Factor Nrf2 Negatively Regulates Autophagy and Growth Arrest Induced by the Anticancer Redox Agent Mitoquinone *. Rao, V. Ashutosh et al. Journal of Biological Chemistry. 2010.DOI: 10.1074/jbc.M110.133579 Source

Involvement of reactive oxygen species in 2-methoxyestradiol-induced apoptosis in human neuroblastoma cells. Zhang, Qi et al. Cancer Letters. 2011.DOI: 10.1016/j.canlet.2011.09.005 Source

Mitochondria-Targeted Drugs Synergize with 2-Deoxyglucose to Trigger Breast Cancer Cell Death. Cheng, Gang et al. Cancer Research. 2012.DOI: 10.1158/0008-5472.CAN-11-3928 Source

Khz (Fusion of Ganoderma lucidum and Polyporus umbellatus Mycelia) Induces Apoptosis by Increasing Intracellular Calcium Levels and Activating JNK and NADPH Oxidase-Dependent Generation of Reactive Oxygen Species. Kim, Tae Hwan et al. PLOS ONE. 2012.DOI: 10.1371/journal.pone.0046208 Source

Carbon Ion Beams Induce Hepatoma Cell Death by NADPH Oxidase-Mediated Mitochondrial Damage. Sun, Chao et al. Journal of Cellular Physiology. 2014.DOI: 10.1002/jcp.24424 Source

Atg7- and Keap1-dependent autophagy protects breast cancer cell lines against mitoquinone-induced oxidative stress. Gonzalez, Yanira et al. Oncotarget. 2014.DOI: 10.18632/oncotarget.1715 Source

Mitoquinone restores platelet production in irradiation-induced thrombocytopenia. Ramsey, Haley et al. Platelets. 2015.DOI: 10.3109/09537104.2014.935315 Source

Abstract 2917: Therapeutic targeting of the mitochondria: An evaluation of the transcriptional link between the antioxidant response and autophagy. Pokrzywinski, Kaytee L. et al. Cancer Research. 2016.DOI: 10.1158/1538-7445.AM2016-2917 Source

Abstract 1090: microRNA regulation of Nrf2 and the antioxidant response in breast cancer cells following redox therapy. Mascia, Francesca et al. Cancer Research. 2016.DOI: 10.1158/1538-7445.AM2016-1090 Source

Inhibiting Lactate Dehydrogenase A Enhances the Cytotoxicity of the Mitochondria Accumulating Antioxidant, Mitoquinone, in Melanoma Cells. Alshamrani, Ali A. et al. Human Skin Cancer, Potential Biomarkers and Therapeutic Targets. 2016.DOI: http://dx.doi.org/10.5772/64231 Source

Suppression of B-RafV600E melanoma cell survival by targeting mitochondria using triphenyl-phosphonium-conjugated nitroxide or ubiquinone. Hong, Seung-Keun et al. Cancer Biology & Therapy. 2017.DOI: 10.1080/15384047.2016.1250987 Source

MitoQ regulates autophagy by inducing a pseudo-mitochondrial membrane potential. Sun, Chao et al. Autophagy. 2017.DOI: 10.1080/15548627.2017.1280219 Source

Abstract 1505: Breast cancer cells treated with mitochondria targeted redox active agents induce mitophagy. Biel, Thomas; Rao, Ashutosh. Cancer Research. 2017.DOI: 10.1158/1538-7445.AM2017-1505 Source

Abstract 466: Role of miR-15b-3p in mitoquinone induced autophagy of breast cancer cells. Mascia, Francesca et al. Cancer Research. 2017.DOI: 10.1158/1538-7445.AM2017-466 Source

ROS production induced by BRAF inhibitor treatment rewires metabolic processes affecting cell growth of melanoma cells. Cesi, Giulia et al. Molecular Cancer. 2017.DOI: 10.1186/s12943-017-0667-y Source

Mitochondrial dysfunction activates lysosomal-dependent mitophagy selectively in cancer cells. Biel, Thomas G. et al. Oncotarget. 2017.DOI: 10.18632/oncotarget.23171 Source

Induction of autophagy by depolarization of mitochondria. Lyamzaev, Konstantin G. et al. Autophagy. 2018.DOI: 10.1080/15548627.2018.1436937 Source

Cyclovirobuxine D Induces Apoptosis and Mitochondrial Damage in Glioblastoma Cells Through ROS-Mediated Mitochondrial Translocation of Cofilin. Zhang, Lin et al. Frontiers in Oncology. 2021.DOI: 10.3389/fonc.2021.656184 Source

Disrupted mitochondrial homeostasis coupled with mitotic arrest generates antineoplastic oxidative stress. Hao, Xiaohe et al. Oncogene. 2022.DOI: 10.1038/s41388-021-02105-9 Source

Low-level laser prevents doxorubicin-induced skeletal muscle atrophy by modulating AMPK/SIRT1/PCG-1α-mediated mitochondrial function, apoptosis and up-regulation of pro-inflammatory responses. Ou, Hsiu-Chung et al. Cell & Bioscience. 2021.DOI: 10.1186/s13578-021-00719-w Source

In search of autophagy biomarkers in breast cancer: Receptor status and drug agnostic transcriptional changes during autophagy flux in cell lines. Mascia, Francesca et al. PLOS ONE. 2022.DOI: 10.1371/journal.pone.0262134 Source

Targeting prooxidant MnSOD effect inhibits triple-negative breast cancer (TNBC) progression and M2 macrophage functions under the oncogenic stress. Al Haq, Aushia Tanzih et al. Cell Death & Disease. 2022.DOI: 10.1038/s41419-021-04486-x Source

Role of Mitochondrial Dysfunction in the Pathogenesis of Cisplatin-Induced Myotube Atrophy. Matsumoto, Chinami et al. Biological & Pharmaceutical Bulletin. 2022.DOI: 10.1248/bpb.b22-00171 Source

Mechanisms involved in mitoquinone-mediated protection of H9C2 cells against anti-cancer drug doxorubicin-induced cardiotoxicity. Mercado, Kelly. PCOM Biomedical Studies Student Scholarship. 2022.Source

Cationic antimicrobial peptide NRC-03 induces oral squamous cell carcinoma cell apoptosis via CypD-mPTP axis-mediated mitochondrial oxidative stress. Hou, Dan et al. Redox Biology. 2022.DOI: 10.1016/j.redox.2022.102355 Source

Depletion of COPI in cancer cells: the role of reactive oxygen species in the induction of lipid accumulation, noncanonical lipophagy and apoptosis. Gasparian, A. et al. Molecular Biology of the Cell. 2022.DOI: 10.1091/mbc.E21-08-0420 Source

Viscoelastic Liquid Matrix with Faster Bulk Relaxation Time Reinforces the Cell Cycle Arrest Induction of the Breast Cancer Cells via Oxidative Stress. Najmina, Mazaya et al. International Journal of Molecular Sciences. 2022.DOI: 10.3390/ijms232314637 Source

A Mitochondrial Switch Promotes Tumor Metastasis. Porporato, Paolo E. et al. Cell Reports. 2014.DOI: 10.1016/j.celrep.2014.06.043 Source

Mutant KRas-Induced Mitochondrial Oxidative Stress in Acinar Cells Upregulates EGFR Signaling to Drive Formation of Pancreatic Precancerous Lesions. Liou, Geou-Yarh et al. Cell Reports. 2016.DOI: 10.1016/j.celrep.2016.02.029 Source

Opening of voltage dependent anion channels promotes reactive oxygen species generation, mitochondrial dysfunction and cell death in cancer cells. DeHart, David N. et al. Biochemical Pharmacology. 2018.DOI: 10.1016/j.bcp.2017.12.022 Source

Activation of c-Met in cancer cells mediates growth-promoting signals against oxidative stress through Nrf2-HO-1. Chakraborty, Samik et al. Oncogenesis. 2019.DOI: 10.1038/s41389-018-0116-9 Source

DNA damage signalling from the placenta to foetal blood as a potential mechanism for childhood leukaemia initiation. Mansell, Els et al. Scientific Reports. 2019.DOI: 10.1038/s41598-019-39552-0 Source

A truncating mutation in the autophagy gene UVRAG drives inflammation and tumorigenesis in mice. Quach, Christine et al. Nature Communications. 2019.DOI: 10.1038/s41467-019-13475-w Source

Molecular mechanism of mitoquinol mesylate in mitigating the progression of hepatocellular carcinoma—in silico and in vivo studies. Sulaimon, Lateef Adegboyega et al. Journal of Cellular Biochemistry. 2021.DOI: 10.1002/jcb.29937 Source

Mitoquinol mesylate alleviates oxidative damage in cirrhotic and advanced hepatocellular carcinogenic rats through mitochondrial protection and antioxidative effects. Sulaimon, Lateef A. et al. Advances in Redox Research. 2021.DOI: 10.1016/j.arres.2021.100014 Source

Doxorubicin suppresses chondrocyte differentiation by stimulating ROS production. Wu, Cheng et al. European Journal of Pharmaceutical Sciences. 2021.DOI: 10.1016/j.ejps.2021.106013 Source

Mitochondrial ROS drive resistance to chemotherapy and immune-killing in hypoxic non-small cell lung cancer. Salaroglio, Iris C. et al. Journal of Experimental & Clinical Cancer Research. 2022.DOI: 10.1186/s13046-022-02447-6 Source

Abstract PS17-55: Reactive oxygen species scavengers in triple negative breast cancer. Duhoux, Francois P et al. Cancer Research. 2021.DOI: 10.1158/1538-7445.SABCS20-PS17-55 Source

Oxidative Stress at the Crossroads of Aging, Stroke and Depression. Shao, Anwen et al. Aging and Disease. 2020.DOI: 10.14336/AD.2020.0225 Source

Mitochondrial Dysfunction in Intervertebral Disc Degeneration: From Pathogenesis to Therapeutic Target. Li, Danni; Tao, Fenghua; Jin, Lin. Oxidative Medicine and Cellular Longevity. 2020.DOI: 10.1155/2020/8880320 Source

Antioxidants Targeting Mitochondrial Oxidative Stress: Promising Neuroprotectants for Epilepsy. Yang, Nan et al. Oxidative Medicine and Cellular Longevity. 2020.DOI: 10.1155/2020/6687185 Source

Reactive Oxygen Species Interact With NLRP3 Inflammasomes and Are Involved in the Inflammation of Sepsis: From Mechanism to Treatment of Progression. Zhao, Shuai et al. Frontiers in Physiology. 2020.DOI: 10.3389/fphys.2020.571810 Source

Mitochondria-Targeted Drug Delivery in Cardiovascular Disease: A Long Road to Nano-Cardio Medicine. Forini, Francesca et al. Pharmaceutics. 2020.DOI: 10.3390/pharmaceutics12111122 Source

Targeted Antioxidants in Exercise-Induced Mitochondrial Oxidative Stress: Emphasis on DNA Damage. Williamson, Josh; Davison, Gareth et al. Antioxidants. 2020.DOI: 10.3390/antiox9111142 Source

Oxidative Stress in Amyotrophic Lateral Sclerosis: Pathophysiology and Opportunities for Pharmacological Intervention. Cunha-Oliveira et al. Oxidative Medicine and Cellular Longevity. 2020.DOI: 10.1155/2020/5021694 Source

Coenzyme Q10 Supplementation for the Reduction of Oxidative Stress: Clinical Implications in the Treatment of Chronic Diseases. Gutierrez-Mariscal et al. International Journal of Molecular Sciences. 2020.DOI: 10.3390/ijms21217870 Source

Dietary Antioxidants and the Mitochondrial Quality Control: Their Potential Roles in Parkinson’s Disease Treatment. Lee, Davin et al. Antioxidants. 2020.DOI: 10.3390/antiox9111056 Source

The Role Played by Mitochondria in FcεRI-Dependent Mast Cell Activation. Chelombitko, Maria A. et al. Frontiers in Immunology. 2020.DOI: /10.3389/fimmu.2020.584210 Source

Traumatic Brain Injury: Oxidative Stress and Novel Anti-Oxidants Such as Mitoquinone and Edaravone. Ismail, Helene et al. Antioxidants. 2020.DOI: 10.3390/antiox9100943 Source

Oxidative Stress in Ozone-Induced Chronic Lung Inflammation and Emphysema: A Facet of Chronic Obstructive Pulmonary Disease. Wiegman, Coen H. et al. Frontiers in Immunology. 2020.DOI: 10.3389/fimmu.2020.01957 Source

Mitochondrial dysfunction in kidney injury, inflammation, and disease: potential therapeutic approaches. Bhatia, Divya; Capili, Allyson; Choi, Mary E. Kidney Research and Clinical Practice. 2020.DOI: 10.23876/j.krcp.20.082 Source

Antioxidant Modulation of mTOR and Sirtuin Pathways in Age-Related Neurodegenerative Diseases. Abdullah, Asmaa et al. Molecular Neurobiology. 2020.DOI: 10.1007/s12035-020-02083-1 Source

Molecular Perspectives of Mitochondrial Adaptations and Their Role in Cardiac Proteostasis. Alam, Shafiul et al. Frontiers in Physiology. 2020.DOI: https://doi.org/10.3389/fphys.2020.01054 Source

Protective role of mitoquinone against impaired mitochondrial homeostasis in metabolic syndrome. Yang, Jing; Suo, Huayi; Song, Jiajia. Critical Reviews in Food Science and Nutrition. 2021.DOI: 10.1080/10408398.2020.1809344 Source

Mechanisms and Functions of Mitophagy and Potential Roles in Renal Disease. Zuo, Zhenying et al. Frontiers in Physiology. 2020.DOI: 10.3389/fphys.2020.00935 Source

Mitochondrial DNA: A New Predictor of Diabetic Kidney Disease. Huang, Yajing et al. International Journal of Endocrinology. 2020.DOI: 10.1155/2020/3650937 Source

Manganese Superoxide Dismutase Dysfunction and the Pathogenesis of Kidney Disease. Kitada, Munehiro et al. Frontiers in Physiology. 2020.DOI: 10.3389/fphys.2020.00755 Source

Mitochondrial and Redox-Based Therapeutic Strategies in Huntington's Disease. Fão, Lígia; Rego, Ana Cristina. Antioxidants & Redox Signaling. 2021.DOI: 10.1089/ars.2019.8004 Source

The interplay between oxidative stress and bioenergetic failure in neuropsychiatric illnesses: can we explain it and can we treat it?. Morris, G. et al. Molecular Biology Reports. 2020.DOI: 10.1007/s11033-020-05590-5 Source

Abnormal Mitochondrial Quality Control in Neurodegenerative Diseases. Yan, Xu et al. Frontiers in Cellular Neuroscience. 2020.DOI: 10.3389/fncel.2020.00138 Source

Mitochondrial Dysfunction and DNA Damage in the Context of Pathogenesis of Atherosclerosis. Shemiakova, Taisiia et al. Biomedicines. 2020.DOI: 10.3390/biomedicines8060166 Source

Targeted antioxidants as therapeutics for treatment of pneumonia in the elderly. Lee, Stefi F. et al. Translational Research. 2020.DOI: 10.1016/j.trsl.2020.03.002 Source

Mitochondrial Determinants of Doxorubicin-Induced Cardiomyopathy. Wallace, Kendall B. et al. Circulation Research. 2020.DOI: 10.1161/CIRCRESAHA.119.314681 Source

Prevention of Cognitive Decline in Alzheimer’s Disease by Novel Antioxidative Supplements. Tadokoro, Koh et al. International Journal of Molecular Sciences. 2020.DOI: 10.3390/ijms21061974 Source

Mitochondria-Targeted Therapeutics for Alzheimer's Disease: The Good, the Bad, the Potential. Mi, Yashi et al. Antioxidants & Redox Signaling. 2021.DOI: 10.1089/ars.2020.8070 Source

Mitochondrial Redox Hubs as Promising Targets for Anticancer Therapy. Ippolito, Luigi et al. Frontiers in Oncology. 2020.DOI: 10.3389/fonc.2020.00256 Source

Nutraceuticals: An integrative approach to starve Parkinson’s disease. Lama, Adriano et al. Brain, Behavior, & Immunity - Health. 2020.DOI: 10.1016/j.bbih.2020.100037 Source

Mitochondrial reactive oxygen species: the effects of mitochondrial ascorbic acid vs untargeted and mitochondria-targeted antioxidants. Fiorani, Mara et al. International Journal of Radiation Biology. 2021.DOI: 10.1080/09553002.2020.1721604 Source

The NRF2 Signaling Network Defines Clinical Biomarkers and Therapeutic Opportunity in Friedreich’s Ataxia. La Rosa, Piergiorgio et al. International Journal of Molecular Sciences. 2020.DOI: 10.3390/ijms21030916 Source

Neutrophil-Related Oxidants Drive Heart and Brain Remodeling After Ischemia/Reperfusion Injury. Carbone, Federico et al. Frontiers in Physiology. 2020.DOI: https://doi.org/10.3389/fphys.2019.01587 Source

Triphenylphosphonium (TPP)-Based Antioxidants: A New Perspective on Antioxidant Design. Wang, Jiayao Y. et al. ChemMedChem. 2020.DOI: 10.1002/cmdc.201900695 Source

Dynamin-related protein 1: A protein critical for mitochondrial fission, mitophagy, and neuronal death in Parkinson’s disease. Feng, Si-Tong et al. Pharmacological Research. 2020.DOI: 10.1016/j.phrs.2019.104553 Source

The Emerging Role of Mitophagy in Kidney Diseases. Bhatia, Divya; Choi, Mary E. Journal of life sciences (Westlake Village, Calif.) 2019.DOI: 10.36069/jols/20191203 Source

The Role of Adipose Tissue Mitochondria: Regulation of Mitochondrial Function for the Treatment of Metabolic Diseases. Lee, Jae Ho et al. International Journal of Molecular Sciences. 2019.DOI: 10.3390/ijms20194924 Source

The Signaling of Cellular Senescence in Diabetic Nephropathy. Xiong, Yabing; Zhou, Lili. Oxidative Medicine and Cellular Longevity. 2019.DOI: 10.1155/2019/7495629 Source

A Mitochondrial Approach to Cardiovascular Risk and Disease. Veloso, Caroline D. et al. A Mitochondrial Approach to Cardiovascular Risk and Disease. 2019.DOI: 10.2174/1389203720666190830163735 Source

Placental Ageing in Adverse Pregnancy Outcomes: Telomere Shortening, Cell Senescence, and Mitochondrial Dysfunction. Manna, Samprikta et al. Oxidative Medicine and Cellular Longevity. 2019.DOI: 10.1155/2019/3095383 Source

Pharmacological Protection of Kidney Grafts from Cold Perfusion-Induced Injury. Krzywonos-Zawadzka, Anna et al. BioMed Research International. 2019.DOI: 10.1155/2019/9617087 Source

Mitochondria-Targeted Antioxidants as Potential Therapy for the Treatment of Traumatic Brain Injury. Stelmashook, Elena V. et al. Antioxidants. 2019.DOI: 10.3390/antiox8050124 Source

Mitochondria-Targeted Antioxidants for Treatment of Hearing Loss: A Systematic Review. Fujimoto, Chisato; Yamasoba, Tatsuya. Antioxidants. 2019.DOI: 10.3390/antiox8040109 Source

Small molecules as therapeutic drugs for Alzheimer's disease. Oliver, Darryll M. A.; Reddy, P. Hemachandra. Molecular and Cellular Neuroscience. 2019.DOI: 10.1016/j.mcn.2019.03.001 Source

Pro- and antitumor effects of mitochondrial reactive oxygen species. Payen, Valéry L. et al. Cancer and Metastasis Reviews. 2019.DOI: 10.1007/s10555-019-09789-2 Source

Regulation of mitochondrial function as a promising target in platelet activation-related diseases. Fuentes, Eduardo et al. Free Radical Biology and Medicine. 2019.DOI: 10.1016/j.freeradbiomed.2019.01.007 Source

Targeting Mitochondria in Age-Related Vascular Changes. Masi, Stefano; Virdis, Agostino. Hypertension. 2018.DOI: 10.1161/HYPERTENSIONAHA.118.10869 Source

Mitochondria-targeting drug conjugates for cytotoxic, anti-oxidizing and sensing purposes: current strategies and future perspectives. Battogtokh, Gantumur et al. Acta Pharmaceutica Sinica B. 2018.DOI: 10.1016/j.apsb.2018.05.006 Source

Mitochondria-Targeted Drugs. Zinovkin, Roman A.; Zamyatnin, Andrey A. Current Molecular Pharmacology. 2019.DOI: 10.2174/1874467212666181127151059 Source

Potential therapy strategy: targeting mitochondrial dysfunction in sepsis. Zhang, Hui; Feng, Yong-wen; Yao, Yong-ming. Military Medical Research. 2018.DOI: 10.1186/s40779-018-0187-0 Source

Mitochondria as a therapeutic target for common pathologies. Murphy, Michael P.; Hartley, Richard C. Nature Reviews Drug Discovery. 2018.DOI: 10.1038/nrd.2018.174 Source

Targeting Mitochondrial Oxidative Stress to Mitigate UV-Induced Skin Damage. Brand, Rhonda M. et al. Frontiers in Pharmacology. 2018.DOI: 10.3389/fphar.2018.00920 Source

Mitochondria-Targeted Antioxidants and Skeletal Muscle Function. Broome, Sophie C.; Woodhead, Jonathan S. T.; Merry, Troy L. Antioxidants. 2018.DOI: 10.3390/antiox7080107 Source

Platelet mitochondrial dysfunction and mitochondria-targeted quinone-and hydroquinone-derivatives: Review on new strategy of antiplatelet activity. Fuentes, Manuel et al. Biochemical Pharmacology. 2018.DOI: 10.1016/j.bcp.2018.08.035 Source

Mitochondrial abnormalities in Parkinson's disease and Alzheimer's disease: can mitochondria be targeted therapeutically?. Macdonald, Ruby et al. Biochemical Society Transactions. 2018.DOI: 10.1042/BST20170501 Source

Mitochondria: Targeting mitochondrial reactive oxygen species with mitochondriotropic polyphenolic-based antioxidants. Teixeira, José et al. The International Journal of Biochemistry & Cell Biology. 2018.DOI: 10.1016/j.biocel.2018.02.007 Source

Targeting Mitochondria to Counteract Age-Related Cellular Dysfunction. Madreiter-Sokolowski et al. Genes. 2018.DOI: 10.3390/genes9030165 Source

Mitochondrial dysfunction and oxidative stress in metabolic disorders — A step towards mitochondria based therapeutic strategies. Bhatti, Jasvinder Singh et al. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2017.DOI: 10.1016/j.bbadis.2016.11.010 Source

Mitochondrial Targeted Therapies: Where Do We Stand in Mental Disorders?. Ben-Shachar, Dorit; Ene, Hila M. Biological Psychiatry. 2018.DOI: 10.1016/j.biopsych.2017.08.007 Source

Targeting Mitochondrial Calcium Handling and Reactive Oxygen Species in Heart Failure. Dietl, Alexander; Maack, Christoph. Current Heart Failure Reports. 2017.DOI: 10.1007/s11897-017-0347-7 Source

Mitochondria-targeted Antioxidants as a Prospective Therapeutic Strategy for Multiple Sclerosis. Fetisova, Elena et al. Current Medicinal Chemistry. 2017.DOI: 10.2174/0929867324666170316114452 Source

Mitochondria-Targeted Triphenylphosphonium-Based Compounds: Syntheses, Mechanisms of Action, and Therapeutic and Diagnostic Applications. Zielonka, Jacek et al. Chemical Reviews. 2017.DOI: 10.1021/acs.chemrev.7b00042 Source

Mitochondria-Targeted Rechargeable Antioxidants as Potential Anti-Aging Drugs. Pasyukova, E.G.; Feniouk, Boris; Skulachev, Vladimir. 2017.DOI: 10.1039/9781782626602-00205 Source

Cellular and Molecular Mechanisms of Action of Mitochondria-Targeted Antioxidants. Feniouk, Boris A.; Skulachev, Vladimir P.. Current Aging Science. 2017.DOI: 10.2174/1874609809666160921113706 Source

Oxidative stress in sepsis: Pathophysiological implications justifying antioxidant co-therapy. Prauchner, Carlos André. Burns. 2017.DOI: 10.1016/j.burns.2016.09.023 Source

Mitochondria-Targeted Antioxidants and Uncouplers of Oxidative Phosphorylation in Treatment of the Systemic Inflammatory Response Syndrome (SIRS). Zakharova, Vlada V. et al. Journal of Cellular Physiology. 2017.DOI: 10.1002/jcp.25626 Source

Understanding and preventing mitochondrial oxidative damage. Murphy, Michael P. Biochemical Society Transactions. 2016.DOI: 10.1042/BST20160108 Source

Application of Mitochondria-Targeted Pharmaceuticals for the Treatment of Heart Disease. Mailloux, Ryan J. Current Pharmaceutical Design. 2016.DOI: 10.2174/1381612822666160629070914 Source

Targeting Mitochondria in Cardiovascular Diseases. Silva, Filomena S. G. et al. Current Pharmaceutical Design. 2016.DOI: 10.2174/1381612822666160822150243 Source

Targeting mitochondrial function to treat optic neuropathy. Gueven, Nuri et al. Mitochondrion. 2017.DOI: 10.1016/j.mito.2016.07.013 Source

Mitochondrial function in hypoxic ischemic injury and influence of aging. Ham, P. Benson; Raju, Raghavan. Progress in Neurobiology. 2017.DOI: 10.1016/j.pneurobio.2016.06.006 Source

Mitochondria-Targeted Antioxidants: Future Perspectives in Kidney Ischemia Reperfusion Injury. Kezic, Aleksandra et al. Oxidative Medicine and Cellular Longevity. 2016.DOI: 10.1155/2016/2950503 Source

Mitochondrion-Permeable Antioxidants to Treat ROS-Burst-Mediated Acute Diseases. Zhang, Zhong-Wei et al. Oxidative Medicine and Cellular Longevity. 2015.DOI: 10.1155/2016/6859523 Source

Rejuvenating cellular respiration for optimizing respiratory function: targeting mitochondria. Agrawal, Anurag; Mabalirajan, Ulaganathan. American Journal of Physiology-Lung Cellular and Molecular Physiology. 2016.DOI: 10.1152/ajplung.00320.2015 Source

Paving the way for therapeutic prevention of tumor metastasis with agents targeting mitochondrial superoxide. Porporato, Paolo E; Sonveaux, Pierre. Molecular & Cellular Oncology. 2015.DOI: 10.4161/23723548.2014.968043 Source

A review on mitochondrial restorative mechanism of antioxidants in Alzheimer’s disease and other neurological conditions. Kumar, Anil; Singh, Arti. Frontiers in Pharmacology. 2015.DOI: doi.org/10.3389/fphar.2015.00206 Source

Protective Effects of Melatonin and Mitochondria-targeted Antioxidants Against Oxidative Stress: A Review. Ramis, M. R. et al. Current Medicinal Chemistry. 2015.DOI: 10.2174/0929867322666150619104143 Source

Mitochondrial Targeted Antioxidant in Cerebral Ischemia. Ahmed, Ejaz et al. Journal of neurology and neuroscience. 2015.DOI: 10.21767/2171-6625.100017 Source

Molecular Strategies for Targeting Antioxidants to Mitochondria: Therapeutic Implications. Apostolova, Nadezda; Victor, Victor M. Antioxidants & Redox Signaling. 2015.DOI: 10.1089/ars.2014.5952 Source

Mitochondria-targeted antioxidants. Oyewole, Anne O.; Birch-Machin, Mark A. FASEB journal: official publication of the Federation of American Societies for Experimental Biology. 2015.DOI: FASEB journal: official publication of the Federation of American Societies for Experimental Biology Source

Quality control systems in cardiac aging. Quarles, Ellen K. et al. Ageing Research Reviews. 2015.DOI: 10.1016/j.arr.2015.02.003 Source

Methodology for Use of Mitochondria-Targeted Cations in the Field of Oxidative Stress-Related Research. Vyssokikh, Mikhail Y. et al. Mitochondrial Medicine: Volume II, Manipulating Mitochondrial Function.2015.Source

Tenofovir-induced nephrotoxicity: incidence, mechanism, risk factors, prognosis and proposed agents for prevention. Jafari, Atefeh et al. European Journal of Clinical Pharmacology. 2014.DOI: 10.1007/s00228-014-1712-z Source

Mitochondria-targeted agents: Future perspectives of mitochondrial pharmaceutics in cardiovascular diseases. Ajith, Thekkuttuparambil Ananthanarayanan; Jayakumar, Thankamani Gopinathan. World Journal of Cardiology.2014.DOI: 10.4330/wjc.v6.i10.1091 Source

Strategies for oral delivery and mitochondrial targeting of CoQ10. Zaki, Noha M. Drug Delivery. 2016.DOI: 10.3109/10717544.2014.993747 Source

Chapter Ten - Advances in Development of Rechargeable Mitochondrial Antioxidants. Lukashev, Alexander N. et al. Progress in Molecular Biology and Translational Science. 2014.Source

Mitochondria-targeted antioxidants for treatment of Parkinson's disease: Preclinical and clinical outcomes. Jin, Huajun et al. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2014.DOI: 10.1016/j.bbadis.2013.09.007 Source

Mitochondria-targeted therapies for acute kidney injury. Tábara, Luis Carlos et al. Expert Reviews in Molecular Medicine. 2014.DOI: 10.1017/erm.2014.14 Source

Mitochondrial oxidative stress in aging and healthspan. Dai, Dao-Fu et al. Longevity & Healthspan. 2014.DOI: 10.1186/2046-2395-3-6 Source

Targeting mitochondria for cardioprotection: examining the benefit for patients. Dongworth, Rachel K. et al. Future Cardiology. 2014.DOI: 10.2217/fca.14.6 Source

Mitochondrial Enhancement for Neurodegenerative Movement Disorders: A Systematic Review of Trials Involving Creatine, Coenzyme Q10, Idebenone and Mitoquinone. Liu, Jia; Wang, Lu-ning. CNS Drugs. 2014.DOI: 10.1007/s40263-013-0124-4 Source

Chapter 19 - Mitochondria-Targeted Antioxidants and Alzheimer’s Disease. Skulachev, Vladimir P. et al. Aging. 2014.DOI: 10.1016/B978-0-12-405933-7.00019-6 Source

Perspectives and Potential Applications of Mitochondria-Targeted Antioxidants in Cardiometabolic Diseases and Type 2 Diabetes. Rocha, Milagros et al. Medicinal Research Reviews. 2014.DOI: 10.1002/med.21285 Source

The role of amyloid-beta in the regulation of memory. Morley, John E.; Farr, Susan A. Biochemical Pharmacology. 2014.DOI: 10.1016/j.bcp.2013.12.018 Source

Cationic antioxidants as a powerful tool against mitochondrial oxidative stress. Skulachev, Vladimir P.. Biochemical and Biophysical Research Communications. 2013.DOI: 10.1016/j.bbrc.2013.10.063 Source

Mitochondria-targeted antioxidants and metabolic modulators as pharmacological interventions to slow ageing. Gruber, Jan et al. Biotechnology Advances. 2013.DOI: 10.1016/j.biotechadv.2012.09.005 Source

Targeting mitochondrial reactive oxygen species as novel therapy for inflammatory diseases and cancers. Li, Xinyuan et al. Journal of Hematology & Oncology 2013.DOI: 10.1186/1756-8722-6-19 Source

Mitochondria as a Therapeutic Target in Heart Failure. Bayeva, Marina; Gheorghiade, Mihai; Ardehali, Hossein. Journal of the American College of Cardiology. 2013.DOI: 10.1016/j.jacc.2012.08.1021 Source

Loss of Mitochondrial Control Impacts Renal Health. Srivastava, Swayam Prakash et al. Frontiers in Pharmacology. 2020DOI: 10.3389/fphar.2020.543973 Source

Oxidative and nitrosative stress in the maintenance of myocardial function. Zhang, Yixuan et al. Free Radical Biology and Medicine. 2012.DOI: 10.1016/j.freeradbiomed.2012.07.010 Source

Mitochondrial pharmacology. Smith, Robin A. J et al. Trends in Pharmacological Sciences. 2012.DOI: 10.1016/j.tips.2012.03.010 Source

Manganese superoxide dismutase, MnSOD and its mimics. Miriyala, Sumitra et al. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2012.DOI: 10.1016/j.bbadis.2011.12.002 Source

Metabolic syndrome and mitochondrial dysfunction: insights from preclinical studies with a mitochondrially targeted antioxidant. Mitchell, Tanecia; Darley-Usmar, Victor. Free Radical Biology and Medicine 2012.DOI: 10.1016/j.freeradbiomed.2011.12.014 Source

Mitochondria-Targeted Antioxidants as Promising Drugs for Treatment of Age-Related Brain Diseases. Skulachev, Vladimir P.. Journal of Alzheimer's Disease. 2012.DOI: 10.3233/JAD-2011-111391 Source

Pharmacological targeting of mitochondrial complex I deficiency: The cellular level and beyond. Roestenberg, Peggy et al. Mitochondrion. 2012.DOI: 10.1016/j.mito.2011.06.011 Source

Antioxidants as Therapeutic Agents for Liver Disease. Singal, Ashwani K. et al. Liver international : official journal of the International Association for the Study of the Liver.2011.DOI: 10.1111/j.1478-3231.2011.02604.x Source

Mitochondria as Potential Targets in Antidiabetic Therapy. Moreira, Paula I.; Oliveira, Catarina R. Diabetes - Perspectives in Drug Therapy. 2011.Source

Mitochondria-targeted Antioxidants as Therapies. Smith, Robin A. J.; Murphy, Michael P.. Discovery Medicine. 2011.Source

Mitochondria-Targeted Small Molecule Therapeutics and Probes. Smith, Robin A.J. et al. Antioxidants & Redox Signaling. 2011.DOI: 10.1089/ars.2011.3969 Source

Targeting mitochondrial dysfunction and neurodegeneration by means of coenzyme Q10 and its analogues. Orsucci, D. et al. Current Medicinal Chemistry. 2011.DOI: 10.2174/092986711796957257 Source

Importance of Oxidative Damage on the Electron Transport Chain for the Rational Use of Mitochondria-Targeted Antioxidants. Cortes-Rojo, C.; Rodriguez-Orozco, A. R. Mini-Reviews in Medicinal ChemistryDOI: 10.2174/138955711795906879 Source

Metabolic manipulators: a well founded strategy to combat mitochondrial dysfunction. Koene, Saskia; Smeitink, Jan. Journal of Inherited Metabolic Disease. 2011.DOI: 10.1007/s10545-010-9162-y Source

Mitochondrial Dysfunction and Oxidative Stress in Asthma: Implications for Mitochondria-Targeted Antioxidant Therapeutics. Reddy, P. Hemachandra. Pharmaceuticals. 2011.DOI: 10.3390/ph4030429 Source

Principles and therapeutic relevance for targeting mitochondria in aging and neurodegenerative diseases. Serviddio, Gaetano et al. Current Pharmaceutical Design. 2011.DOI: 10.2174/138161211796904740 Source

Mitochondrial dysfunction and targeted drugs: a focus on diabetes. Victor, Victor M. et al. Current Pharmaceutical Design. 2011.DOI: 10.2174/138161211796904722 Source

Therapeutic use of coenzyme Q10 and coenzyme Q10-related compounds and formulations. Villalba, Jose M et al. Expert Opinion on Investigational Drugs. 2010.DOI: 10.1517/13543781003727495 Source

Mitochondrially Targeted Antioxidants for the Treatment of Cardiovascular Diseases. Subramanian, Sharath et al. Recent Patents on Cardiovascular Drug Discovery. 2010.DOI: 10.2174/157489010790192601 Source

Mitochondria--a neglected drug target. Murphy, Michael P. Current Opinion in Investigational Drugs (London, England: 2000) 2009.Source

An attempt to prevent senescence: A mitochondrial approach. Skulachev, Vladimir P. et al. Biochimica et Biophysica Acta (BBA) - Bioenergetics. 2009.DOI: 10.1016/j.bbabio.2008.12.008 Source

Mitochondria-Targeted Antioxidants in the Treatment of Disease. Smith, Robin A.J. et al. Annals of the New York Academy of Sciences. 2008.DOI: 10.1196/annals.1427.003 Source

Mitochondrial Approaches for Neuroprotection. Chaturvedi, Rajnish K.; Beal, M. Flint. Annals of the New York Academy of Sciences. 2008.DOI: 10.1196/annals.1427.027 Source

Pathophysiological and pharmacological implications of mitochondria-targeted reactive oxygen species generation in astrocytes. Jou, Mei-Jie. Advanced Drug Delivery Reviews. 2008.DOI: 10.1016/j.addr.2008.06.004 Source

Targeting lipophilic cations to mitochondria. Murphy, Michael P. Biochimica et Biophysica Acta (BBA) - Bioenergetics. 2008.DOI: 10.1016/j.bbabio.2008.03.029 Source

Mitochondria-Directed Therapeutics. Armstrong, Jeffrey S. Antioxidants & Redox Signaling. 2008.DOI: 10.1089/ars.2007.1929 Source

MitoQ--a mitochondria-targeted antioxidant. Tauskela, Joseph S. IDrugs: the investigational drugs journal. 2007.Source

Targeting antioxidants to mitochondria and cardiovascular diseases: the effects of mitoquinone. Milagros Rocha, Milagros; Victor, Victor Manuel. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research.2007.Source

Mitochondrial targeting of quinones: Therapeutic implications. Cochemé, Helena M. et al. Mitochondrion. 2007.DOI: 10.1016/j.mito.2007.02.007 Source

Targeting Antioxidants to Mitochondria by Conjugation to Lipophilic Cations.. Murphy, Michael P.; Smith, Robin A.J. Annual Review of Pharmacology and Toxicology. 2007.DOI: 10.1146/annurev.pharmtox.47.120505.105110 Source

Targeting antioxidants to mitochondria: A new therapeutic direction. Sheu, Shey-Shing; Nauduri, Dhananjaya; Anders, M. W. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2006.DOI: 10.1016/j.bbadis.2005.10.007 Source

Mitochondrial Oxidative Damage in Aging and Alzheimer's Disease: Implications for Mitochondrially Targeted Antioxidant Therapeutics. Reddy, P. Hemachandra. BioMed Research International. 2006.DOI: 10.1155/JBB/2006/31372 Source

How to Clean the Dirtiest Place in the Cell: Cationic Antioxidants as Intramitochondrial ROS Scavengers. Skulachev, Vladimir P. IUBMB Life. 2005.DOI: 10.1080/15216540500092161 Source

Mitochondrially targeted antioxidants and thiol reagents. Coulter, Carolyn V. et al. Free Radical Biology and Medicine. 2000.DOI: 10.1016/S0891-5849(00)00255-0 Source

Drug delivery to mitochondria: the key to mitochondrial medicine. Murphy, Michael P; Smith, Robin A. J. Advanced Drug Delivery Reviews. 2000.DOI: 10.1016/S0169-409X(99)00069-1 Source

Editorial: Diabetic kidney disease: routes to drug development, pharmacology and underlying molecular mechanisms. Bhatia, Divya; Srivastava, Swayam Prakash. Frontiers in Pharmacology. 2023.DOI: 10.3389/fphar.2023.1252315 Source

Chapter Ten - Targeting mitochondrial dysfunction to salvage cellular senescence for managing neurodegeneration. Sharma, Komal et al. Advances in Protein Chemistry and Structural Biology. 2023.Source

Targeting Inflammation and Oxidative Stress as a Therapy for Ischemic Kidney Injury. Andrianova, N. V. et al. Biochemistry (Moscow). 2020DOI: 10.1134/S0006297920120111 Source

Targeting the Mitochondrial Permeability Transition Pore to Prevent Age-Associated Cell Damage and Neurodegeneration. Kent, Andrew C. et al. Oxidative Medicine and Cellular Longevity. 2021DOI: 10.1155/2021/6626484 Source

Coenzyme Q10 Analogues: Benefits and Challenges for Therapeutics. Suárez-Rivero, Juan M. et al. Antioxidants. 2021DOI: 10.3390/antiox10020236 Source

Mitochondrial Dysfunction and Oxidative Stress in Alzheimer’s Disease. Misrani, Afzal et al. Frontiers in Aging Neuroscience. 2021DOI: https://doi.org/10.3389/fnagi.2021.617588 Source

Targeting mitochondrial dysfunction with small molecules in intervertebral disc aging and degeneration. Saberi, Morteza et al. GeroScience. 2021DOI: 10.1007/s11357-021-00341-1 Source

Role of mitochondria, oxidative stress and the response to antioxidants in myalgic encephalomyelitis/chronic fatigue syndrome: A possible approach to SARS-CoV-2 ‘long-haulers’?. Wood, Emily et al. Chronic Diseases and Translational Medicine. 2020DOI: 10.1016/j.cdtm.2020.11.002 Source

Self-Associating Polymers Chitosan and Hyaluronan for Constructing Composite Membranes as Skin-Wound Dressings Carrying Therapeutics. Valachová, Katarína et al. Molecules. 2021DOI: 10.3390/molecules26092535 Source

Therapeutic Potential and Immunomodulatory Role of Coenzyme Q10 and Its Analogues in Systemic Autoimmune Diseases. López-Pedrera, Chary et al. Antioxidants. 2021DOI: 10.3390/antiox10040600 Source

Coenzyme Q10 Effects in Neurological Diseases. RAUCHOVÁ, Hana. Physiological Research. 2021DOI: 10.33549/physiolres.934712 Source

Mitochondrial Dysfunction in Cardiovascular Diseases: Potential Targets for Treatment. Yang, Jiaqi et al. Frontiers in Cell and Developmental Biology. 2022DOI: 10.3389/fcell.2022.841523 Source

Mechanisms of Mitochondrial Malfunction in Alzheimer’s Disease: New Therapeutic Hope. Nabi, Showkat Ul et al. Oxidative Medicine and Cellular Longevity. 2022DOI: 10.1155/2022/4759963 Source

Editorial: Metabolic Adaptation of Muscle Tissue in Diseases Associated With Cachexia. Cirillo, Federica et al. Frontiers in Cell and Developmental Biology. 2022DOI: 10.3389/fcell.2022.947902 Source

Mitochondrial nanomedicine: Subcellular organelle-specific delivery of molecular medicines. Milane, Lara et al. Nanomedicine: Nanotechnology, Biology and Medicine. 2021DOI: 10.1016/j.nano.2021.102422 Source

Mitochondrial impairment and repair in the pathogenesis of systemic lupus erythematosus. Zhao, Like et al. Frontiers in Immunology. 2022DOI: 10.3389/fimmu.2022.929520 Source

Mitochondrial Medicine: A Promising Therapeutic Option Against Various Neurodegenerative Disorders. Almikhlafi, Mohannad A. et al. Current Neuropharmacology. 2022DOI: 10.2174/1570159X20666220830112408 Source

Mitoquinone mesylate attenuates brain inflammation in humanized mouse model of chronic HIV infection. Satta, Sandro et al. AIDS. 2022DOI: 10.1097/QAD.0000000000003291 Source

Mitochondrial Stress in Metabolic Inflammation: Modest Benefits and Full Losses. Yuan, Qing et al. Oxidative Medicine and Cellular Longevity. 2022DOI: 10.1155/2022/8803404 Source

Oxidative Regulation of Vascular Cav1.2 Channels Triggers Vascular Dysfunction in Hypertension-Related Disorders. Hu, Xiang-Qun et al. Antioxidants. 2022DOI: 10.3390/antiox11122432 Source

The Therapeutic Strategies Targeting Mitochondrial Metabolism in Cardiovascular Disease. Huang, Xiaoyang et al. Pharmaceutics. 2022DOI: 10.3390/pharmaceutics14122760 Source

Application Prospects of Triphenylphosphine-Based Mitochondria-Targeted Cancer Therapy. Cheng, Xiaoxia et al. Cancers. 2023DOI: 10.3390/cancers15030666 Source

Targeting mitochondrial fitness as a strategy for healthy vascular aging. Rossman et al. Clinical Science (Lond). 2020DOI: 10.1042/CS20190559 Source

Mitochondria-targeted nutraceuticals in sports medicine: a new perspective. Ostojic SM. Res Sports Med. 2016DOI: 10.1080/15438627.2016.1258646 Source

Animal and human studies with the mitochondria-targeted antioxidant MitoQ. Smith RA et al. Annals of the New York Academy of Sciences. 2011DOI: 10.1111/j.1749-6632.2010.05627.x Source

The Effect of MitoQ on Aging-Related Biomarkers: A Systematic Review and Meta-Analysis. Braakhuis A et al. Oxidative Medicine and Cellular Longevity. Volume 2018DOI: 10.1155/2018/8575263 Source