Depression is a common mental disorder that affects more than 350 million people worldwide. There’s no simple answer as to why people become depressed, but experts do know it is more common in certain families; after stressful events such as bereavements, break-ups, or job losses; or with financial hardship.
Oxidative stress has been linked as a factor for major depression.
Depression is associated with changes in brain levels of neurotransmitters (chemical such as serotonin and dopamine that help transport messages from one part of the brain to another). Higher levels of inflammation, mitochondrial dysfunction, and oxidative stress have also featured in studies of people with depression.
This article, published in the journal of Oxidative Medicine and Cellular Longevity, reviews the connection between oxidative stress and depression. It looks at the possibility of using markers of oxidative stress to monitor for depression status and the effectiveness of various antidepressants. Use of omega-3 fatty acids, polyphenols and antioxidants such as coenzyme Q10 and N-acetyl cysteine to counteract free radicals and correct imbalances is also discussed.
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